Phlebodia 600 film-coated tablets of 600 mg, 30 pcs

Chronic venous insufficiency is often hidden and widespread in modern society. Pain, heaviness in the legs, night cramps, swelling until the evening are the reasons for contacting a phlebologist. A sedentary lifestyle, improper nutrition, genetic predisposition, pregnancy are the main risk factors for the development of chronic venous diseases. The most effective in eliminating the symptoms of this pathology are preparations based on the micronized purified fraction of flavonoids. The technology of micronization means reducing the diameter of the microparticles of the substance to improve the absorption of the drug in the mucous membrane of the gastrointestinal tract.

Phlebodia 600 is a capillary-stabilizing drug consisting of a purified flavonoid fraction. The unique substance – semi-synthetic diosmin – determines the main pharmacotherapeutic effects of the drug – venotonic and angioprotective.

The mechanism of action of the original drug Phlebodia is implemented by reducing capillary permeability and venous distensibility. Diosmin affects the assimilation of the hormone norepinephrine, which maintains venous tone and provokes a vasoconstrictor effect. It prevents the interaction of leukocytes with the endothelium of vessels, thanks to which the inflammatory process is suppressed. Based on this, the complex action of the drug is ensured:

• stimulation of lymphatic outflow;
• improvement of microcirculation;
• suppression of inflammation;
• improvement of oxygen supply to tissues;
• increases the tone and frequency of contraction of lymphatic capillaries;
• protection of venous valves.

Phlebodia is produced by the French pharmaceutical company “Innotera Shuzi” and is an original drug. On the Ukrainian pharmaceutical market, there is a tablet form of 600 mg of the active substance in one tablet.

Symptomatic treatment of venolymphaticheksoy insufficiency of various degrees of severity and hemorrhoids are the main indications for the use of Phlebodia. It should be taken into account that in case of lymphovenous insufficiency, the tablet is taken on an empty stomach before breakfast, and in case of acute hemorrhoids – during a meal.

Phlebodia refers to phlebotropic drugs with an evidence base of effectiveness and safety. The advantages of Phlebodia are the multifaceted mechanism of action on various links and the cause of the pathology, the rapid development of the effect, the minimum number of contraindications and undesirable manifestations during the treatment period. Phlebodia in tablet form can be used in the complex therapy of diseases of the veins of the lower extremities.

Composition and form of release

Composition

Active substance in the 1st tablet: diosmin (corresponds to Diosmin anhydrous pure) – 600 mg

Excipients: microcrystalline cellulose, talc, stearic acid, colloidal anhydrous silicon dioxide, shell (hypromellose, microcrystalline cellulose, macrogol stearate 400), Opaglos 6000 (palm wax, yellow wax, humilac, ethanol 95%), Sepisperse dye (cochineal red A (E 124), propylene glycol, hypromellose, titanium dioxide (E 171), iron oxide red (E172), iron oxide black (E172)).

Release form

Film-coated tablets.

Indication

• Relief of symptoms of lymphovenous insufficiency: heaviness in the legs, pain, trophic disorders.
• Complex treatment of functional conditions accompanied by increased permeability of capillaries.
• Treatment of functional symptoms of acute hemorrhoids.

Contraindication

Increased sensitivity to the components of the drug, especially in patients prone to allergic reactions to cochineal red A (E 124). The drug is not recommended for use during breastfeeding.

Method of application and dosage

For oral use.

• Lymphovenous insufficiency: 1 tablet a day in the morning before breakfast. The duration of the treatment course is determined by the doctor depending on the course of the disease. The average duration of treatment is 2 months.
• Acute hemorrhoids: 2-3 tablets per day during meals for 7 days. If the symptoms of hemorrhoids do not disappear after treatment, you should consult a doctor to correct the treatment. The maximum daily dose is 1800 mg (3 tablets).

Children. Not used.

Features of application

Phlebodia 600 mg increases the tone of small-caliber veins, as a result of which it improves venous outflow and lymphatic drainage. Venous tone increases due to increased tropism of wall noradrenaline in venous myocytes (increases the synthesis and/or release of noradrenaline; inhibits the activity of catechol-o-methyltransferase; moderately reduces the activity of phosphodiesterase). The vasoconstrictor effect of the drug applies only to the venous and lymphatic channels. The drug does not affect the tone of the arteries. In animals, Phlebodia 600 mg improves tissue trophicity and microcirculation, reduces tissue swelling due to a decrease in the permeability of capillaries and an increase in their resistance. The drug has a moderate antiplatelet and anti-inflammatory effect. In humans, the anti-inflammatory effect is realized due to anti-complimentary activity, inhibition of the reaction of the release of peroxide anions, and a decrease in the production of leukotrienes.

Use during pregnancy or breastfeeding

Pregnant women should use with caution. Consult your doctor before use. As a precaution, it is advisable to avoid the use of the drug during pregnancy. Due to the lack of data on the penetration of the drug into breast milk, the use of this drug during breastfeeding should be avoided. A decision to discontinue breast-feeding or to discontinue/abstain from treatment with Phlebodia 600 must be made taking into account the benefit of breast-feeding for the child and the benefit of therapy for the woman.

The ability to influence the speed of reaction when driving vehicles or other mechanisms

No studies on the effect of diosmin on the ability to drive vehicles or work with other mechanisms have been conducted. Despite this, according to the safety profile of diosmin in different countries of the world, the drug Phlebodia 600 has little or no effect on the speed of reaction when driving a motor vehicle or working with other mechanisms.

Adverse reactions

From the side of the gastrointestinal tract: in isolated cases, gastrointestinal disorders rarely lead to discontinuation of treatment.

To reduce the frequency of adverse reactions, it is necessary to take the medicine together with food.

Overdose

Cases of drug overdose have not been reported.

Storage conditions

Store in the original packaging at a temperature not higher than 25 °C in a place inaccessible to children. Shelf life – 5 years. Do not use the drug after the expiration date indicated on the package.