Cystinol Akut film-coated tablets 30 pieces

Pharmacodynamics. In vitro, preparations of bearberry leaves have antibacterial activity against Proteus vulgaris, E. coli, Ureaplasma urealyticum, Mycoplasma hominis, Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumoniae, Enterococcus faecalis, Streptococcus strains, and Candida albicans.

The antibacterial effect is mainly associated with the aglycone of hydroquinone, which is released from arbutin or from products formed during the excretion of arbutin. When hydroquinone is released from conjugates (hydroquinone glucuronide and sulfate), the enzymatic activity of microorganisms that cause urinary tract infections is blocked.

At the same time, the extract of common bearberry leaves, due to the presence of tannins, reduces the adhesion of bacteria to the host cell.

Pharmacokinetics. Arbutin from bearberry leaves (prodrug) is adsorbed in the small intestine and undergoes fermentation, and is also metabolized in the liver. As a result, hydroquinone conjugates are converted by a second-pass reaction to hydroquinone glucuronide and sulfate. These non-toxic compounds are water-soluble and excreted in the urine.

In metabolic studies involving healthy volunteers (Cystinol Acute, film-coated tablets), 70% of the administered dose of arbutin was excreted in the urine as conjugated hydroquinone within 24 hours. Recovery of the active substance in the form of free hydroquinone was 0.5% of the administered dose of arbutin.

Microbiological studies on E. coli have shown that fermentation of conjugates occurs over a wide range of intrabacterial interactions and is independent of urine pH. In addition, the antiseptic effect is enhanced only in the area where bacteria are present.

Inflammatory diseases of the lower urinary tract.

Adults and adolescents over 12 years of age are prescribed 2 tablets 3 times a day. The tablets should be washed down with plenty of liquid, preferably water, and taken after meals.

Unless otherwise prescribed by a doctor, a medicine containing arbutin should be used for no more than 1 week and no more than 5 times a year.

Children: Do not use in children under 12 years of age.

Hypersensitivity to bearberry leaves or other components of the drug.

Assessment of side effects by frequency of occurrence is carried out as follows: very often (≥1/10); often (≥1/100 to 1/10); sometimes (≥1/1000 to 1/100); rarely (≥1/10,000 to 1/1000); very rarely (1/10,000); frequency unknown (cannot be estimated from the available data).

Very rarely, patients with hypersensitivity of the stomach may complain of symptoms from the digestive tract (nausea, vomiting, abdominal pain, diarrhea).

Nervous system: dizziness.

Rarely, allergic reactions may occur, such as: rash, itching.

If side effects develop, treatment should be discontinued and a doctor should be consulted to assess their severity.

The doctor should decide on further action as necessary.

If hematuria occurs, body temperature rises, or if complaints persist for more than 5 days, you should consult a doctor.

Patients with hereditary galactose intolerance, lactase deficiency and glucose-galactose malabsorption should not use this drug.

Use during pregnancy and breastfeeding. Not prescribed during pregnancy or breastfeeding.

The ability to influence the reaction speed when driving vehicles or working with other mechanisms. Does not affect.

Cystinol acute film-coated tablets contain an extract of mountain ash leaves and therefore should not be used together with drugs that increase urine acidity, as a decrease in the antibacterial effect of mountain ash leaves cannot be ruled out.

Symptoms: when using the drug in doses exceeding the recommended ones, gastrointestinal disorders such as vomiting, nausea, hematuria and liver damage may occur.

Treatment: immediately stop taking the drug and consult a doctor. Therapy is symptomatic.

In the original packaging at a temperature not exceeding 25 °C.

Keep out of reach of children.