Loperamide tablets of 2 mg, 20 pcs

• active substance: loperamide hydrochloride;
• 1 tablet contains loperamide hydrochloride in the calculation of 100% substance – 2 mg;
• excipients: lactose, monohydrate; potato starch; calcium stearate.

Loperamide is not indicated for the initial treatment of severe diarrhea associated with decreased fluid and electrolyte levels. In particular, in children, it is desirable to compensate for this loss by prescribing parenteral or oral replacement therapy.

Tablets should be taken without chewing, with water.

Symptomatic treatment of acute diarrhea in adults and children over 12 years of age

The initial dose is 2 tablets (4 mg), then 1 tablet (2 mg) after each subsequent liquid bowel movement. The usual dose is 3-4 tablets (6-8 mg) per day. The maximum daily dose for acute diarrhea should not exceed 6 tablets (12 mg).

Symptomatic treatment of acute attacks of diarrhea due to irritable bowel syndrome in adults aged 18 years and older after initial diagnosis by a physician

The initial dose is two tablets (4 mg); in the future, take 1 tablet (2 mg) after each case of liquid stools or according to the previous recommendations of the doctor. The maximum daily dose should not exceed 6 tablets (12 mg).

In acute diarrhea, if there is no clinical improvement within 48 hours, loperamide should be discontinued.

• patients with known hypersensitivity to loperamide hydrochloride or to any of the components of the drug;
• children under 12 years of age;
• patients with acute dysentery, characterized by the presence of blood in stools and elevated body temperature;
• patients with acute ulcerative colitis or pseudomembranous colitis associated with the use of broad-spectrum antibiotics;
• patients with bacterial enterocolitis caused by microorganisms of the families Salmonella, Shigella and Campylobacter.

From the side of the nervous system: headache.

From the side of the digestive tract: constipation, flatulence, nausea.

From the side of the nervous system: dizziness.

From the digestive tract: dry mouth, flatulence, abdominal pain and discomfort, vomiting, upper abdominal pain, dyspepsia.

Dehydration and electrolyte imbalance may occur in patients with diarrhea, especially children, debilitated patients, and the elderly. In such cases, the most important measure is the use of replacement therapy to replenish fluid and electrolytes.

The use of the drug does not replace the introduction of an appropriate amount of fluid and restoration of electrolytes.

Use during pregnancy or breastfeeding

It is not recommended to take this medicine during pregnancy and breastfeeding.

Children

The drug should be used in children over 12 years of age for the symptomatic treatment of acute diarrhea.

The ability to influence the speed of reaction when driving vehicles or other mechanisms

It is recommended to take this drug with caution when driving a car or working with mechanisms.

In case of overdose (including relative overdose due to impaired liver function), depression of the central nervous system (stupor, incoordination, drowsiness, miosis, muscle hypertonus, respiratory depression), urinary retention and a complex of symptoms similar to intestinal obstruction may occur.

Simultaneous administration of loperamide (in a dose of 16 mg) together with inhibitors of P-glycoprotein (quinidine, ritonavir) led to an increase in the level of loperamide in blood plasma by 2-3 times. The clinical significance of the indicated pharmacokinetic interaction when using loperamide in recommended doses is unknown.

Store in the original packaging at a temperature not higher than 25ºС.

Keep out of the reach of children.