Avenue film-coated tablets 500 mg 50 pieces

Pharmacodynamics. Avenue has a venotonic and angioprotective effect, increases venous tone, reduces venous distensibility and venostasis, improves microcirculation, reduces capillary permeability and increases their resistance, improves lymphatic drainage, increasing lymphatic outflow.

The drug also reduces the interaction of leukocytes and endothelium, leukocyte adhesion in postcapillary venules. This reduces the harmful effects of inflammatory mediators on the walls of veins and the leaflets of vein valves.

Pharmacokinetics. T _½ is 11 hours.

The active substance is excreted mainly through the intestines. An average of 14% of the administered dose is excreted in the urine.

Symptomatic treatment of venolymphatic insufficiency (heaviness in the legs, pain, swelling). Symptomatic treatment of hemorrhoids.

For oral use. For adults.

Treatment of venolymphatic insufficiency (symptoms: swelling, pain, heaviness in the legs, night cramps, trophic ulcers, lymphedema).

The recommended dose is 2 tablets per day: 1 tablet in the afternoon and 1 tablet in the evening, during meals. After a week of use, you can take 2 tablets per day at the same time during meals.

Treatment of chronic hemorrhoids. 2 tablets per day (in two divided doses) with meals. After a week of use, you can take 2 tablets per day once with meals.

Treatment of acute hemorrhoids. 6 tablets per day for 4 days, then 4 tablets per day for the next 3 days. Take with meals. Divide the daily dose into 2-3 doses.

Course of treatment. The duration of treatment depends on the indication for use and the course of the disease. The average duration of treatment is 2-3 months.

Children: There are no data on the use of Avenue in children.

Hypersensitivity to the active substance or any of the excipients.

From the nervous system: dizziness, headache, malaise;

Gastrointestinal: diarrhea, dyspepsia, nausea, vomiting, colitis;

Skin and subcutaneous tissue: rash, itching, urticaria, isolated swelling of the face, lips, eyelids, angioedema.

The use of this medicinal product for acute hemorrhoids does not replace specific treatment and does not interfere with therapy for other proctological diseases. If symptoms do not disappear quickly during a short course of treatment, a proctological examination should be performed and the therapy reviewed.

In cases of venous circulation disorders, more effective treatment is provided by combining therapy with adherence to the following lifestyle recommendations:

• avoid prolonged exposure to the sun, prolonged standing, and excess body weight;
• walk and in some cases wear special stockings to improve blood circulation.

Use during pregnancy and breastfeeding. The drug should be used with caution in pregnant women. Consult a doctor before use.

Studies have not revealed any teratogenic effects of the drug, and no side effects have been reported.

Due to the lack of data on the penetration of the drug into breast milk, the use of the drug during breastfeeding should be avoided.

Ability to influence the reaction rate when driving vehicles or working with other mechanisms. The drug does not affect the ability to drive vehicles and work with various mechanisms. If signs of side effects of the drug appear (see Side effects), caution should be exercised.

Interaction studies have not been conducted. However, there is extensive post-marketing experience with diosmin, and no interactions with other drugs have been reported to date.

No cases of overdose have been reported.

In the original packaging at a temperature not exceeding 25 °C.