Bifren Plus capsules to support normal functioning of the nervous system, reduce fatigue and tiredness 20 pcs.

GABA is formed from glutamate by the addition of glutamate decarboxylase and vitamin B6 and is released into the postsynaptic terminals of neurons. GABA is an amino acid that serves as the main inhibitory neurotransmitter in the brain and the main inhibitory neurotransmitter in the spinal cord. It performs its main function in the synapse between neurons by binding to postsynaptic GABA receptors, which modulate ion channels, hyperpolarizing the cell and inhibiting the transmission of action potentials. GABAergic neurons are located in the hippocampus, thalamus, basal ganglia, hypothalamus and brainstem. The balance between inhibitory neuronal transmission through GABA and excitatory neuronal transmission through glutamate is important for proper cell membrane stability and neurological function. Helps maintain activity, memory, perception of the environment, especially in the elderly. Promotes mental concentration. Stimulates physical and mental abilities.

Magnesium is a mineral involved in stress and its responses. On the one hand, stress contributes to a decrease in magnesium levels, and on the other hand, exogenous or endogenous magnesium deficiency increases the stress response. It is important to maintain adequate magnesium levels in order to better respond to stress. In situations of micronutrient deficiency, magnesium supplementation can support mental performance (e.g. concentration, learning, memory, reasoning) and may protect brain function. Supplementation with B vitamins and magnesium can reduce fatigue.

Vitamin B1 (thiamine) is a water-soluble vitamin involved in carbohydrate and protein metabolism. Thiamine supports the proper functioning of the nervous system and contributes to normal psychological function.

Vitamin B6 (pyridoxine) is a water-soluble vitamin that is necessary to maintain energy and overall vitality. Ensures normal functioning of tissues and systems of the body, especially in old age. Stimulates physical performance. In situations of deficiency, it can support mental performance. Helps maintain activity, memory, perception of the environment, especially in the elderly. Pyridoxine promotes mental concentration, stimulates mental abilities, soothes, promotes healthy sleep and improves psycho-emotional state.

Glycine is the simplest amino acid synthesized by the body and is a building block for protein. Glycine is typically synthesized from choline, serine, hydroxyproline, and threonine by intracellular metabolism, primarily involving the kidneys and liver. Glycine acts as a precursor to several key low-molecular-weight metabolites, such as creatine, glutathione, heme, purines, and porphyrins.

Glycine is one of the main neurotransmitters in the central nervous system and plays an important role in regulating neural activity. It has several properties that can affect nervous system function and performance. Glycine acts as an inhibitory neurotransmitter, which means that it can slow down or reduce the activity of nerve cells in some parts of the brain. This can lead to calmness and reduced feelings of anxiety. Glycine is also involved in the regulation of sleep and wakefulness. Glycine can improve sleep quality and reduce the time it takes to fall asleep, as well as reduce daytime wakefulness.

Bifren Plus can be recommended as a dietary supplement to the diet as an additional source of GABA, glycine, magnesium, vitamin B1, B6. A balanced combination of nutrients contributes to: maintaining normal functioning of the nervous system, reducing fatigue and tiredness, normal mental activity during increased physical and mental stress. The components of the complex have a positive effect on maintaining mental activity, the functioning of the nervous system, including during emotional imbalance and stress.

Not recommended for use in case of individual hypersensitivity to the main ingredients; children and adolescents under 18 years of age, pregnant or breastfeeding women. This product is not intended for the diagnosis, treatment or prevention of any disease, and should not be used as a substitute for a complete diet. Do not exceed the recommended daily dose. Do not use after the expiration date indicated on the package.

Before use, consultation with a doctor is mandatory.

It is not a medicine.

Adults: 2 capsules daily or as recommended by a doctor. Take with meals, with water.

Duration of use is 1 month, after which the duration of use should be agreed with the doctor.

1 capsule of 550 mg contains:

• Gamma-aminobutyric acid (GABA) 150 mg (mg);
• Glycine 150 mg (mg);
• Magnesium 60 mg (mg);
• Vitamin B1 2.5 mg (mg);
• Vitamin B6 1.5 mg (mg).

Gamma-aminobutyric acid (GABA), glycine, magnesium carbonate, filler (microcrystalline cellulose), colloidal silicon dioxide, anti-caking agent (magnesium stearate), vitamin B1 (thiamine hydrochloride), vitamin B6 (pyridoxine hydrochloride).

GMO-free.

Store in the original packaging at a temperature not exceeding 25 °C and out of the reach of children.