Combispasm is indicated for pain syndromes with a spastic component of various origins:
- headache;
- toothache;
- muscle pain, neuralgia;
- rheumatic pain, radiculitis;
- renal colic;
- menstrual pain.
Composition
Active ingredients: paracetamol, dicyclomine hydrochloride;
1 tablet contains paracetamol 500 mg, dicyclomine hydrochloride 20 mg;
Excipients: corn starch, microcrystalline methylcellulose, povidone, magnesium stearate, talc, colloidal anhydrous silicon dioxide, sodium starch glycolate (type A).
Contraindication
Hypersensitivity to the components of the drug. Glaucoma, tachycardia, urinary tract obstruction, benign prostatic hypertrophy with a tendency to urinary retention, severe renal and/or hepatic dysfunction, glucose-6-phosphate dehydrogenase deficiency, alcoholism, blood diseases, anemia (including hemolytic), leukopenia. Dynamic intestinal obstruction, paralytic intestinal obstruction, pyloric stenosis of the gastrointestinal tract with obstruction, severe ulcerative colitis, obstructive diseases of the gastrointestinal tract and biliary tract with impaired patency, peptic ulcer of the stomach or duodenum, reflux esophagitis; acute bleeding; congenital hyperbilirubinemia (Gilbert, Dubin-Johnson and Rotor syndromes), myasthenia gravis, thyrotoxicosis, heart failure.
Method of application
The drug should be taken orally, washed down with a small amount of liquid (200 ml).
Adults: 1–2 tablets depending on the severity of the pain 1–4 times a day. When treating adults, it is advisable to start with 4 tablets per day. The maximum dose can be increased to 8 tablets per day, provided that it is well tolerated and there are no side effects.
Application features
Pregnant women
The drug is not recommended for women during pregnancy and breastfeeding.
Children
The drug should not be prescribed to children under 7 years of age.
Drivers
Since dicyclomine hydrochloride may cause adverse reactions from the nervous system and visual organs, when using the drug, you should refrain from driving vehicles and working with other mechanisms.
Overdose
Treatment.
In case of overdose, urgent medical attention is required. Treatment should be started immediately. The patient should be taken to hospital immediately, even if there are no early symptoms of overdose.
Symptoms may be limited to nausea and vomiting or may not reflect the severity of the overdose or the risk of organ damage. Gastric lavage, use of activated charcoal (if the overdose of paracetamol was taken within 1 hour). Paracetamol concentration should be measured 4 hours or later after ingestion (earlier concentrations are unreliable). Treatment with
N-acetylcysteine can be used within 24 hours of ingestion, but the maximum protective effect occurs when it is used within 8 hours of ingestion under the control of the respiratory and circulatory systems (adrenaline should not be used). The effectiveness of the antidote decreases sharply after this time. In case of convulsions, diazepam is prescribed. If necessary, the patient should be given
N-acetylcysteine intravenously, according to current recommendations. In the absence of vomiting, oral methionine can be used as a suitable alternative in remote areas outside the hospital.
There is no specific antidote to dicyclomine hydrochloride.
If necessary, symptomatic therapy and peritoneal dialysis should be performed.
General supportive measures should also be taken.
Side effects
The drug is usually well tolerated. Side effects associated with the active substances included in the drug appear, as a rule, with prolonged use of the drug in high doses.
Paracetamol.
From the digestive tract: nausea, vomiting, decreased appetite, constipation, diarrhea or flatulence. With prolonged use of high doses of the drug – pain in the epigastric region.
Interaction
The interaction features of the drug are due to the properties of its components.
Paracetamol, which is part of the drug, reduces the effectiveness of diuretics.
Storage conditions
Store in the original packaging at a temperature not exceeding 25 °C.
Keep out of reach of children.
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