Diazolin Darnytsia tablets of 100 mg 10 pcs

Active substance: mebhydrolin.

Composition

• 1 tablet contains mebhydrolin 100 mg;
• excipients: lactose monohydrate, potato starch, microcrystalline cellulose, povidone, silicon dioxide colloidal anhydrous, magnesium stearate.

Release form

Flat-cylindrical tablets with a bevel and a line, white or white with a yellowish tint.

Pharmacodynamics. the active substance of the drug – mebhydrolin – belongs to antihistamines, is a blocker of hl-receptors. weakens the spasmogenic effect of histamine on the smooth muscles of the bronchi and intestines, and also affects the permeability of blood vessels.

Pharmacokinetics. Mebhydrolin is quickly absorbed in the digestive tract. Bioavailability is 40-60%. The therapeutic effect is achieved after 15-30 minutes, the maximum effect is noted after 1-2 hours. The drug practically does not penetrate the blood-brain barrier. It is metabolized in the liver by methylation. Excreted from the body by the kidneys.

Prevention and treatment of seasonal allergic rhinitis, pollinosis, urticaria, food and drug allergies, dermatoses accompanied by itching (eczema, neurodermatitis).

The drug is used internally after meals.

Adults and children over 12 years of age should use the drug in a dose of 100-200 mg 1-2 times a day. The maximum single dose is 300 mg, daily – 600 mg.

Children aged 5-12 years should use the drug in a dose of 50 mg (½ tablet) 1-3 times a day.

The duration of treatment is determined by the doctor depending on the nature of the disease, the achieved therapeutic effect and the tolerability of the drug.

Hypersensitivity to the active substance or other components of the drug, gastric and duodenal ulcers during exacerbation, inflammatory diseases of the digestive tract, pylorus stenosis, hyperplasia of the prostate gland, glaucoma, epilepsy, heart rhythm disorders.

On the part of the nervous system, psyche and sense organs: headache, dizziness, paresthesias, increased fatigue, drowsiness, blurred visual perception, slowing of the speed of reactions, tremor, irritability, anxiety (at night).

Gastrointestinal tract: dry mouth, dyspeptic phenomena (heartburn, nausea, pain in the epigastric region), irritation of the mucous membrane of the digestive tract.

From the side of the immune system, skin and subcutaneous tissue: hypersensitivity reactions, itching, rash, urticaria, Quincke’s edema.

From the urinary system: urination disorders.

From the blood and lymphatic system: granulocytopenia, agranulocytosis.

Children sometimes have paradoxical reactions: increased excitement, tremors, sleep disturbances.

During the use of the drug, it is not recommended to drink alcoholic beverages and use medicinal products containing ethanol.

The drug should be used with caution in patients with severe hepatic and/or renal insufficiency (it may be necessary to adjust the dose and increase the intervals between doses).

The drug contains lactose, so patients with rare hereditary forms of galactose intolerance, lactase deficiency or glucose-galactose malabsorption syndrome should not use the drug.

Use during pregnancy and breastfeeding. The drug is contraindicated during pregnancy and breastfeeding.

Children. The drug should be used in children aged 5 years and older.

The ability to influence the speed of reaction when driving a motor vehicle or working with other mechanisms. During the use of the drug, it is not recommended to drive vehicles or other mechanisms that require concentration of attention and quick reaction.

The drug enhances the effect of sleeping pills, sedatives and other drugs that depress the central nervous system, as well as alcohol.

Symptoms: confusion, drowsiness, impaired coordination of movements, dry mouth.

Treatment: gastric lavage to clear lavage water, ingestion of activated charcoal, forced diuresis. Further treatment is symptomatic.

In the original packaging at a temperature not higher than 25 °C.