Fervex for adults powder for oral solution in a sachet of 8 pcs

• active substances: paracetamol, ascorbic acid (vitamin C), pheniramine maleate;
• 1 sachet contains paracetamol 500 mg, ascorbic acid (vitamin C) 200 mg, pheniramine maleate 25 mg;
• auxiliary substances: sucrose, anhydrous citric acid, acacia, sodium saccharin, Antillean flavor additive, which includes maltodextrin, acacia, α-pinene, β-pinene, limonene, γ-terpinene, linalool, neral, α-terpineol, geranial.

Hypersensitivity to the components of the drug or to other antihistamines, severe liver and/or kidney function disorders, congenital hyperbilirubinemia, glucose-6-phosphate dehydrogenase deficiency, alcoholism, blood diseases, severe anemia, leukopenia, severe arterial hypertension, unstable angina; severe cardiac conduction disorders, acute period of myocardial infarction, severe atherosclerosis, uncompensated heart failure, hyperthyroidism, acute urinary retention due to prostatic hypertrophy, bladder neck obstruction, pyloroduodenal obstruction, gastric and duodenal ulcer in the acute stage, angle-closure glaucoma, thrombosis, thrombophlebitis , severe forms of diabetes, epilepsy, old age; fructose intolerance, glucose/galactose malabsorption syndrome or sucrose-isomaltose deficiency due to sucrose content, phenylketonuria.

Do not use together with MAO inhibitors and within two weeks after stopping MAO inhibitors. Fervex for adults is contraindicated for patients who take tricyclic antidepressants or β-blockers for urolithiasis – provided that ascorbic acid enters the body in a dose of more than 1 g per day.

From the hematopoietic and lymphatic system: anemia, sulfhemoglobinemia and methemoglobinemia (cyanosis, shortness of breath, heart pain), hemolytic anemia; thrombosis, hyperprothrombinemia, erythrocytopenia, thrombocytopenia, agranulocytosis, neutrophilic leukocytosis, purpura, leukopenia, neutropenia.

From the side of the immune system: anaphylaxis, anaphylactic shock, skin hypersensitivity reactions, including itching, rash on the skin and mucous membranes (usually erythematous, urticaria), angioedema, erythema multiforme (including Stevens-Johnson syndrome), toxic epidermal necrolysis (syndrome Lyella).

From the respiratory system: bronchospasm in patients sensitive to acetylsalicylic acid and other NSAIDs.

From the digestive tract: dry mouth, nausea, heartburn, vomiting, constipation, pain in the epigastrium, diarrhea, impaired liver function, increased activity of liver enzymes, usually without the development of jaundice, hepatonecrosis (dose-dependent effect).

From the endocrine system: hypoglycemia up to hypoglycemic coma.

From the nervous system: rarely – headache, dizziness, sleep disturbance, insomnia, drowsiness, confusion, hallucinations, nervousness, tremors; in some cases – coma, convulsions, dyskinesia, changes in behavior, increased excitability; balance and memory disorders, inattention, especially in elderly patients.

Internally, adults and children over 15 years of age are prescribed 1 sachet 2-3 times a day. Dissolve the contents of the sachet in a sufficient amount of cold or warm water. Take the solution immediately after preparation. It is better for patients with cold symptoms to take a warm solution of the drug in the evening. The interval between receptions should be at least 4 hours.

The maximum duration of treatment is 5 days.

For patients with impaired kidney function (with creatinine clearance less than 10 ml/min), the interval between doses should be at least 8 hours.

If the symptoms of the disease do not disappear or worsen, a doctor’s consultation is required.

Use during pregnancy or breastfeeding

Since the effect of the drug on the course of pregnancy or the period of breastfeeding has not been sufficiently studied, it should not be prescribed during such a period.

Children

Do not use in children under 15 years of age.

The ability to influence the speed of reaction when driving vehicles or other mechanisms

The drug can cause drowsiness, therefore, while taking the drug, you should refrain from driving vehicles or working with other mechanisms.

Related to pheniramine.

An overdose of pheniramine can cause convulsions (especially in children), loss of consciousness, coma.

Associated with paracetamol.

There is a risk of intoxication in the elderly and especially in young children (cases of therapeutic overdose and accidental poisoning occur quite often).

An overdose of paracetamol can be fatal.

Symptoms

Nausea, vomiting, anorexia, pallor, increased sweating, abdominal pain, which usually appear within the first 24 hours.

Overdose of more than 10 g of paracetamol in 1 dose in adults and 150 mg/kg of body weight in

1 dose in children causes hepatic cytolysis, which can lead to complete and irreversible necrosis and hepatocellular failure, metabolic acidosis, encephalopathy, which in turn can lead to coma and death.

At the same time, elevated levels of liver transaminases, lactate dehydrogenase and bilirubin are observed against the background of an increased level of prothrombin, which may appear 12-48 hours after use.

Immediate measures:

• immediate hospitalization;
• determination of the initial level of paracetamol in blood plasma;
• immediate removal of the applied medicinal product by gastric lavage;
• the usual treatment of overdose includes the use of the antidote N-acetylcysteine ​​by intravenous or oral route. The antidote should be applied as early as possible, preferably within 10 hours after the overdose;
• methionine as symptomatic therapy.

Unwanted combinations.

Due to the presence of pheniramine, ethanol increases the sedative effect of H1-blockers, so you should refrain from driving vehicles or working with other mechanisms. During treatment, you should avoid drinking alcoholic beverages and using medicines containing ethyl alcohol.

Store at a temperature not higher than 25 °C in a place inaccessible to children.