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Antimicrobials

Macmiror film-coated tablets 200 mg 20 pcs.

$56.85

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Macmiror 200 mg treats infections of the urinary, intestinal, and genital tracts. Effective against Giardia, Trichomonas, and Candida.

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The active substance of the drug Macmiror is a nitrofuran derivative – nifuratel.

High treatment efficacy is observed in patients with intestinal amebiasis and giardiasis, from 70-90% and 91-94%, respectively. There is also clinical data on the pronounced antiprotozoal activity of nifuratel.

Nifuratel does not cause cross-resistance of microorganisms to other drugs used in the treatment of infections. In 30 years, no case of resistance to nifuratel has been identified.

Pharmacokinetic studies were conducted in healthy volunteers taking 200 mg of nifuratel, during which two kinetic components were detected. After taking a single dose of 200 mg, rapid absorption of nifuratel was noted; the serum concentration 2 hours after administration was 9.48 ± 3.6 μg/ml. Nifuratel was rapidly metabolized in almost all body tissues, the half-life was 2.75 ± 0.8 hours. Approximately 0.5% of nifuratel was excreted in the urine unchanged. The rest was excreted as metabolites. Nifuratel exhibits significant affinity for fats and a significant total distribution, which is 17.428 l. Nifuratel was not detected in the intrahepatic circulation.

Indication

Vulvovaginal infections caused by pathogens sensitive to the drug (pathogenic microorganisms, trichomonads, fungi, yeasts, chlamydia, fungi of the genus Candida).

Diseases of the genitourinary system (cystitis, urethritis, pyelonephritis, pyelitis).

Intestinal amebiasis and giardiasis.

Contraindication

Known individual hypersensitivity to the active substance or other components of the drug. The drug should not be used in cases of impaired renal function, neuropathies and patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency.

Method of administration and doses

Vulvovaginal infections:

  • Adults: 1 tablet of Macmiror 3 times a day after meals for 7 days for the treatment of the woman and her partner, if possible. For local treatment, use Macmiror Complex, soft vaginal capsules or Macmiror Complex, vaginal cream.
  • Important: Patients treated only with tablets should increase the dose to 4 tablets per day. It is necessary to abstain from sexual intercourse during treatment, otherwise it is necessary to use Macmiror Complex, vaginal cream before each sexual act.
  • Children aged 10 years and over, the recommended dose is 10 mg/kg body weight per day, in 2 divided doses. Take the drug after meals. The average duration of treatment is 10 days.

Urinary tract infections:

  • Adults: the recommended dose of the drug depends on the severity of the disease and is 3-6 tablets per day (i.e. 200-400 mg 3 times a day) after meals. The course of treatment is on average 1-2 weeks.
  • Children aged 6 years and over: the recommended dose is 10-20 mg/kg body weight per day, in 2 divided doses. Take after meals. Duration of treatment 7 – 14 days.
  • As prescribed by a doctor, if necessary, the course of treatment with Macmiror can be extended or a repeated course of treatment for urinary tract infections can be prescribed.

Intestinal amebiasis:

  • Adults: 2 tablets 3 times a day after meals for 10 days.
  • Children aged 6 years and over: the recommended daily dose is 30 mg/kg body weight, divided into 3 doses for 10 days.

Intestinal giardiasis:

  • Adults: 2 tablets 2-3 times a day after meals for 7 days.
  • Children aged 6 years and over: the recommended daily dose is 30 mg/kg body weight, divided into 2 doses after meals for 7 days.
  • Children. The drug should be used in children over 6 years of age.

Overdose

Cases of overdose are unknown.

Application features

Use of the drug, especially over a long period of time, may cause hypersensitivity reactions.

During treatment, it is necessary to refrain from drinking alcohol to prevent the development of fatigue and nausea, which pass on their own after some time.

If signs of an allergic reaction occur, the drug should be discontinued.

While using the drug, you should refrain from sexual contact.

It is necessary to treat the sexual partner at the same time to avoid re-infection.

The drug contains sucrose, which should be taken into account by patients with diabetes.

Thrombocytopenic purpura, hepatotoxicity, blood abnormalities and pulmonary reactions have been reported with other nitrofuran compounds. However, a causal relationship between these clinical reactions and Macmiror 200 mg film-coated tablets has not been established. However, their occurrence cannot be completely ruled out.

Composition

active ingredient: nifuratel;

1 tablet contains nifuratel 200 mg

excipients: corn starch, rice starch, polyethylene glycol 6000, talc, magnesium stearate, gelatin, gum arabic, sucrose, magnesium carbonate, titanium dioxide (E 171), wax E, purified water.

Storage conditions

Store at a temperature not exceeding 25 ° C. Keep out of the reach of children!

Shelf life – 5 years.

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