Posterisan forte ointment tube 25 g

1 g of ointment contains (active ingredients):

• 166.70 mg of standardized bacterial culture suspension (containing 5.0×10 ⁸ E. coli killed and preserved in 3.3 mg of liquefied phenol);
• 2.50 hydrocortisone.

Excipients: lanolin, yellow soft paraffin.

Pharmacodynamics

The drug stimulates local immune processes due to antigenic action, causing both nonspecific and specific immune reactions, resulting in increased local immune resistance. Accelerates and improves wound healing, has an anti-inflammatory effect, prevents reinfection and superinfection.

Pharmacokinetics

Due to sorption or transcytosis, components of the bacterial culture suspension act as antigens and initiate the process of local immunization, which, in turn, causes a protective immune response.

• hypersensitivity to the active substance or to any component of the drug;
• specific skin conditions (tuberculosis, syphilis, gonorrhea) in the area of application, chickenpox, reaction to vaccination, fungal diseases, inflammatory diseases of the facial skin (oral dermatitis, rosacea), other bacterial, viral, parasitic infections at the site of application, ulcerative lesions and atrophic changes at the site of application, tumors of the anorectal area.

Before use, it is necessary to carry out hygienic procedures of the anal area. Adults should apply the ointment to the affected area of the skin and mucous membranes 2 times a day (morning and evening), if possible after defecation, carefully rub in with a finger. To introduce the ointment into the anal canal and rectum, you can use the applicator with side holes, which is included in the package.

The duration of treatment is determined by the doctor depending on the nature and course of the disease. Usually the duration of use is 5-7 days.

Pregnant women

Corticosteroids cross the placenta. There is currently no clear evidence of teratogenic effects in humans similar to those observed in animal studies. Effects on the fetus or newborn have been reported with systemic use of high doses of corticosteroids (in utero growth retardation, adrenocortical suppression). Although there is little information on the use of topical corticosteroids during pregnancy, given their limited systemic absorption, weak and moderate-potency corticosteroids (class 1 and class 2), such as hydrocortisone, may be used for short periods of time and on limited skin areas. The above effects cannot be excluded with prolonged use or application to large areas of skin. This should only be done if there are special indications.

Hydrocortisone can be used in breastfeeding women only for short-term treatment and application to small areas of skin. For long-term treatment or application to large areas of affected skin, breastfeeding should be discontinued.

Children

Do not apply.

No cases of overdose or intoxication have been reported. Overdose causes suppression of the function of the hypothalamic-pituitary-adrenal system. In case of accidental ingestion of the ointment (for example, by children), gastrointestinal tract symptoms (abdominal pain, nausea) are possible. Long-term use in large doses increases absorption and increases the risk of developing systemic effects of hydrocortisone, such as menstrual disorders, increased blood pressure, delayed wound healing, muscle weakness, insomnia, increased blood sugar levels. If symptoms of hypercorticism are observed, treatment should be discontinued.

In some cases, patients with hypersensitivity to the components of the ointment “Posterisan Forte” may experience hypersensitivity reactions, including itching and burning, depigmentation, hypertrichosis, dry skin. May cause contact dermatitis (for example, due to hypersensitivity to phenol). With prolonged use of the drug in high doses, the following dermatological reactions are possible: dermatitis, eczema, delayed healing of wounds and cracks, development of secondary infection, atrophy of the mucous membrane, atrophy of the skin, crusting, dilation of capillaries (telangiectasia), the appearance of stretch marks on the skin (stretch marks) and steroid acne.

Store in the original packaging at a temperature not exceeding 25 °C, in a dry place, out of the reach of children and protected from light.

Shelf life – 3 years.