Prostatilen-zinc rectal suppositories (candles) 10 pcs.

Prostatilen-zinc is a combined drug used to treat prostate diseases. Prostatilen, which is part of the suppositories, has an organotropic effect on the prostate gland (prostate protective effect), anti-inflammatory effect, reducing edema and leukocyte infiltration of the gland, improves microcirculation and platelet-vascular hemostasis, has a positive effect on the functional activity of sperm. Prostatilen also stimulates the activity of the humoral link of immunity and some factors of the body’s resistance, affects the tone of the muscles of the bladder, including the tone of the detrusor.

Zinc prevents the development of benign and malignant processes in the prostate gland, helps maintain the integrity of sperm, increases sexual desire, is a factor of immune protection, necessary for the maturation of specific immune cells, the synthesis of cytokines, and the body’s resistance. Zinc deficiency, which is characteristic, in particular, of the elderly, leads to impotence, regression of the male gonads and testicles, and a decrease in the number of sperm.

Vitamin E supports the biological activity of sperm, has anticoagulant properties, prevents intravascular blood clotting, as it has the ability to bind prothrombin, also has anti-inflammatory and pronounced antioxidant effects, and prevents the development of atherosclerosis.

The components of the drug are effectively absorbed in the intestines. Vitamin E in the blood binds to lipoproteins and partially to albumin, is deposited in the adrenal glands, pituitary gland, testicles, adipose and muscle tissues, and liver. It is excreted mainly with bile. Zinc does not accumulate, is excreted with feces (85%), as well as with urine and sweat. There is no information on the pharmacokinetics of prostatilen. Rectal administration of the drug ensures effective entry of active substances into the local bloodstream of the pelvic organs and male genital organs.

Treatment and prevention of chronic prostatitis, benign prostatic hyperplasia, complications after prostate surgery, as well as sexual disorders, male infertility.

Before use, tear off one suppository from the primary packaging along the perforation line of the blister package; then, holding the edges of the film, tear it in different directions and remove the suppository from the primary packaging.

For adults, insert the suppository deep into the anus.

For therapeutic purposes, use 1 suppository 2 times a day (morning and evening) for 5-10 days.

For prevention purposes – 1 suppository once a day.

The duration of treatment is determined by the doctor depending on the nature and severity of the disease, the achieved therapeutic effect, the nature of the therapy (monotherapy or complex treatment). If necessary, the course of treatment can be repeated after 1-6 months.

Hypersensitivity to the components of the drug, renal failure, myocardial infarction, cardiosclerosis. Hypersensitivity to bovine proteins.

Allergic reactions, including itching, redness of the skin, skin rashes, changes at the injection site, including burning. With prolonged use of vitamin E in high doses, decreased blood clotting, bleeding from the gastrointestinal tract, liver enlargement, creatinineuria, fatigue, weakness, headache, nausea, dizziness, blurred vision are possible.

The drug should be prescribed with caution in patients with atherosclerosis and an increased risk of thromboembolism.

When using the drug, it is necessary to adhere to the dosage and duration of treatment prescribed by the doctor to prevent overdose and the occurrence of hypervitaminosis E.

With prolonged use of the drug in high doses, it is necessary to monitor blood clotting time.

Use during pregnancy and breastfeeding. The drug is not used in women.

Children. The drug is not prescribed to children.

Ability to influence the reaction rate when driving vehicles or working with other mechanisms. There are no data on the effect of the drug on the ability to drive vehicles or work with mechanisms. However, in some patients the drug may cause dizziness and blurred vision, so during therapy it is recommended to refrain from activities that require increased concentration of attention and reaction speed (including driving vehicles and mechanisms).

It cannot be used simultaneously with iron, silver preparations, alkaline agents (sodium bicarbonate, trisamine), indirect anticoagulants (dicumarol, ethyl biscumacetate).

Vitamin E enhances the effect of steroid drugs and nonsteroidal anti-inflammatory drugs (diclofenac sodium, ibuprofen, prednisolone), reduces the toxic effect of cardiac glycosides (digitoxin, digoxin), vitamins A and D. The use of vitamin E in high doses can cause vitamin A deficiency in the body. Vitamin E and its metabolites have an antagonistic effect on vitamin K. Vitamin E increases the effectiveness of antiepileptic drugs in patients with epilepsy. Cholestyramine, colestipol, mineral oils reduce the absorption of vitamin E.

There have been no reports of overdose of suppositories with Prostatilen. Overdose of zinc sulfate is characterized by fever, impaired lung function, dehydration, electrolyte imbalance in the blood plasma, and renal failure.

When using the drug in high doses (400 mg/day for a long time), dyspeptic disorders, fatigue, general weakness, headache, creatinuria, increased creatine kinase activity, increased cholesterol and triglyceride concentrations, decreased thyroxine and triiodothyronine concentrations in blood plasma, increased estrogen and androgen levels in urine are possible. There is no specific antidote. Treatment is symptomatic.

At a temperature not exceeding 25 °C.