Sonobarboval drops oral solution bottle 5 ml

1 ml of solution contains (active ingredients):

• ethyl ester of α-bromoisovaleric acid in terms of 100% substance – 18 mg;
• menthol solution in menthyl ester of isovaleric acid (validol) – 80 mg;
• doxylamine hydrogen succinate calculated on 100% dry matter – 16.875 mg.

Excipients: sodium acetate trihydrate; ethanol 96%; purified water.

• increased individual sensitivity to the components of the drug and antihistamines;
• acute angle-closure glaucoma, including a personal or family history;
• urethroprostatic disorders with the risk of urinary retention;
• severe arterial hypotension;
• acute myocardial infarction.

The dose of the drug is set individually, taking into account the severity and duration of insomnia.

The drug is taken once with a small amount of water (1/2 cup) 15-30 minutes before bedtime.

The recommended single dose for adult patients is 12 drops, which corresponds to 7.5 mg of doxylamine. If necessary, the dose can be increased. The maximum single dose is 24 drops (15 mg of doxylamine). 1 ml of solution corresponds to 27 drops.

To prevent the development of daytime drowsiness, it should be taken into account that after taking the drug, the possibility of sleeping for at least 7 hours should be ensured.

The duration of taking the drug is 2-5 days.

Pregnant women

The drug is not prescribed during pregnancy due to the presence of bromine in the composition. It is not recommended to use the drug during lactation.

Children

The drug is not recommended for use in children under 18 years of age, as safety and efficacy have not been established.

Drivers

The drug affects the reaction rate, so you should refrain from driving or working with other mechanisms.

During the next day after taking the drug, the possibility of developing daytime drowsiness, decreased concentration, and impaired accommodation should be taken into account.

In cases of insufficient sleep duration, the risk of impaired reaction speed increases.

Possible only when taking the drug in very high doses.

Symptoms: headache, nausea, cardiac disorders, hypersensitivity reactions to the components of the drug, agitation, delirium, hallucinations, impaired coordination of movements, athetosis, tremor, dilated pupils, accommodation paralysis, dry mouth, redness of the face and neck, hyperthermia, sinus tachycardia, central nervous system depression, ataxia, decreased blood pressure, convulsions, coma.

Acute doxylamine poisoning sometimes causes rhabdomyolysis, which may be complicated by acute renal failure.

Manifestations of chronic bromine poisoning (bromism) include: depression, apathy, rhinitis, conjunctivitis, hemorrhagic diathesis, and impaired coordination of movements. Symptomatic therapy is prescribed to eliminate these manifestations.

Long-term use of the drug is sometimes accompanied by increased psychodynamic activity.

Treatment is symptomatic.

The drug is usually well tolerated by patients. The following adverse reactions may develop:

• from the nervous system: daytime drowsiness, dizziness, inhibition, decreased concentration, hallucinations, confusion, exacerbation of sleep apnea syndrome, increased psychodynamic activity;
• from the digestive system: abdominal discomfort, nausea, dry mouth, constipation;
• Cardiovascular system: tachycardia, arterial hypotension;
• from the immune system: allergic reactions, including skin rashes, itching, urticaria, angioedema;
• on the part of the organs of vision: accommodation disorder, blurred vision, visual defect, lacrimation;
• Urinary system: urinary retention.

Prolonged use of bromine-containing drugs can lead to bromine poisoning, which is characterized by the following symptoms: central nervous system depression, depressed mood, confusion, ataxia, apathy, conjunctivitis, rhinitis, lacrimation, acne, purpura.

Cases of abuse and drug dependence have been reported.

H1 _{-antihistamine} drugs cause sedation, cognitive disorders, and psychomotor impairment.

Store in the original packaging at a temperature not exceeding 25 °C, out of the reach of children.

Shelf life – 3 years.