Venorutinol capsules 300 mg 2 blisters of 10 pcs.

Composition

active ingredient: venorutinol;

1 capsule contains 300 mg of venorutinol (O-(β-hydroxyethyl)-rutosides), calculated as rutin and dry matter;

excipients: macrogol 6000, lactose monohydrate, calcium stearate; the capsules contain the dye Sunset Yellow FCF (E 110).

Release form

Capsules.

Troxerutin is a drug with p-vitamin activity and a pronounced angioprotective effect. The drug reduces vascular tissue permeability and capillary fragility, promotes normalization and improvement of tissue trophism, reduces stagnant phenomena in veins and paravenous areas, exhibits anti-edematous and anti-inflammatory effects, increases the tone of smooth muscles of venous blood vessels; participates in redox processes; stabilizes the activity of hyaluronic acid in cell membranes, blocking the activity of hyaluronidase; increases the density of the vascular wall, reduces exudation of the liquid part of the plasma and diapedesis of formed blood elements. By reducing the manifestations of exudative inflammation in the vessels, troxerutin limits the adhesion of platelets to the surface of the vascular wall. After taking the capsule inside, the drug is well absorbed in the gastrointestinal tract. Cmax of the active substance in plasma is noted on average 2 hours after ingestion. It penetrates the blood-brain barrier well. It is metabolized in the liver to form several metabolites. It is partially excreted unchanged in the urine and bile.

• chronic venous insufficiency with the following manifestations: edema, trophic skin lesions, including leg ulcers;
• after surgical interventions due to varicose veins;
• varicose veins, including during pregnancy (II and III trimesters), superficial thrombophlebitis, phlebitis, periphlebitis, post-phlebitic conditions, post-thrombotic syndrome;
• hemorrhoids;
• in the complex treatment of diabetic retinopathy;
• paresthesias and cramps of the lower extremities at night and upon awakening;
• post-traumatic edema and hematomas.

Venorutinol is taken orally during meals, 1 capsule 2 times a day (morning and evening). Maintenance therapy – 1 capsule per day. Sometimes the desired effect is noted after using a dose of 600 mg (2 capsules) per day.

Gelatin capsules should be swallowed without chewing.

The duration of treatment is determined by the severity of the disease. Usually the course of treatment is 3-4 weeks.

• hypersensitivity to troxerutin and/or any component of the drug;
• gastric and duodenal ulcer, chronic gastritis (in the exacerbation phase);
• childhood.

Capsules. When using Venorutinol capsules, adverse reactions rarely occur.

Gastrointestinal side effects include nausea, vomiting, abdominal pain, diarrhea, and dyspepsia. In rare cases, erosive-ulcerative lesions of the digestive tract may occur.

Possible skin allergic reactions – urticaria, itching; rarely – headache, facial flushing, sleep disturbances.

Capsules. The drug is prescribed with caution to patients with severe liver and gallbladder diseases. Long-term use of venorutinol is not recommended for patients with severe renal dysfunction.

Venorutinol is used during meals, given that it irritates the gastric mucosa.

The drug contains lactose, therefore patients with rare hereditary forms of galactose intolerance, lactase deficiency or glucose-galactose malabsorption syndrome should not use this medicine.

Patients with lower extremity edema caused by heart, kidney, or liver disease should not use the drug, as it is not effective in these conditions.

Use during pregnancy and breastfeeding

Should not be used in the first 3 months of pregnancy.

In the II and III trimesters of pregnancy and during breastfeeding, the drug may be used under the supervision of a physician if the expected benefit to the mother outweighs the potential risk to the fetus/child.

If the drug is used in breastfeeding women, breastfeeding is recommended to be discontinued.

Children

The efficacy and safety of the drug for the treatment of children have not been studied.

The ability to influence the reaction speed when driving or working with other mechanisms

There is no data on the ability of the drug to affect the reaction speed when driving or working with other mechanisms.

Capsules. The drug enhances the effect of ascorbic acid in strengthening the structure and reducing the permeability of the vascular wall.

Capsules. Symptoms of side effects may increase (nausea, diarrhea, dyspepsia, abdominal pain and headache, sleep disturbances, skin allergic reactions).

Treatment is symptomatic. Stop taking the drug, induce vomiting or wash the stomach. If necessary, peritoneal dialysis can be prescribed.

In the original packaging at a temperature not exceeding 25 °C.