Pharmacological properties
The drug Nitrofungin is characterized by antiseptic and disinfectant action on gram-positive and gram-negative bacteria, mycobacteria, some fungi. Active against the causative agent of dermatomycoses. The drug Nitrofungin Neo belongs to the group of undecylenic acid derivatives, has fungicidal and fungistatic action. The fungistatic action is significantly expressed against dermatophytes, facultative pathogenic fungi of the Scropulariopsis species and yeast fungi of the Candida species.
When applied externally, Nitrofungin Neo is not absorbed by the skin.
Phenol is absorbed in the gastrointestinal tract, skin, mucous membranes. It is metabolized into phenylglucuronide and phenylsulfate. A small part of phenol is oxidized to catecholamines and quinol. Metabolites are excreted in the urine, which may acquire a light green color.
Indication
Treatment and prevention of dermatomycoses, especially interdigital/plantar dermatomycoses of the feet, epidermophytosis, trichophytosis, mycotic eczema; candidiasis and mixed skin infections, mycosis of the external auditory canal.
Application
Nitrofungin solution for external use: the drug can be used by adults and children over 15 years of age. The drug solution is applied pointwise or rubbed into the affected areas 2-3 times a day. Duration of treatment – after the disappearance of the signs of the disease, the drug must be used in the same way 1-2 times a week (for the purpose of reliable treatment) for 4 weeks. Failure to follow these recommendations may result in a relapse of the disease.
To prevent relapses, the drug is used 1-2 times a week.
As a rule, an undiluted solution is used. In cases accompanied by severe local inflammation, as well as when skin irritation occurs, a solution of Nitrofungin diluted with water in a ratio of 1: 1 can be used.
Solution for external use and spray for external use Nitrofungin Neo. Adults and children over 2 years of age apply the drug solution topically or rub in 2-3 times a day; spray is applied by spraying on the affected areas of the skin with an interval of 8-12 hours (preferably in the morning and evening) until the symptoms of the disease disappear. To prevent relapse of the disease, it is necessary to continue using the drug after the symptoms disappear in the same way 1-2 times a week for 4 weeks.
Typically, the undiluted solution is used only in cases of acute inflammatory processes on the skin; if skin irritation occurs during treatment, the drug is diluted with water in a 1: 1 ratio.
Contraindication
Nitrofungin: hypersensitivity to chlornitrophenol and other components of the drug, children under 15 years of age.
Nitrofungin Neo: a drug in the form of a solution, spray – for children under 2 years of age.
Side effects
In some cases, skin irritation may occur at the site of application of the drug (hyperemia, itching, swelling, burning sensation, skin rash) or increased skin sensitivity to direct sunlight (photosensitization). In case of adverse reactions, a doctor’s consultation is necessary to determine the feasibility of further use of the drug.
Special instructions
Use during pregnancy and breastfeeding. There is no sufficient experience of using the drug during this period, so treatment is possible only after careful determination of the appropriateness of its appointment. If within 3-7 days of use there is no therapeutic effect or the manifestations of the disease worsen, it is necessary to stop using it and review the treatment tactics. If skin irritation or skin rash appears at the site of application of the drug, its use should be discontinued. Areas treated with Nitrofungin should be protected from direct sunlight.
The drug does not affect the ability to drive vehicles and work with complex mechanisms.
Interactions
No data.
Overdose
Cases of overdose with topical application of Nitrofungin have not been described.
Accidental ingestion of phenol causes nausea, vomiting, increased sweating, and diarrhea. After the initial disturbance, the patient may faint.
After ingestion of phenol, the stomach should be washed with a solution containing olive or other vegetable oil to prevent its further absorption. Activated charcoal is prescribed.
Storage conditions
In a place protected from light at a temperature of 10-25 °C.












