Micogel gel 20 mg/g tube 15 g

Pharmacodynamics. Micogel is an antimycotic and antibacterial drug.

The active substance of the drug – miconazole nitrate – inhibits the biosynthesis of ergosterol and changes the lipid composition of the membrane, causing the death of the fungal cell. It has a pronounced antifungal effect on dermatophytes (Microsporum canis, Trichophyton rubrum, Epidermophyton floccosum), fungi of the genus Candida, Cryptococcus and some others, as well as fungi of the genus Aspergillus. It has antibacterial activity against gram-positive microorganisms (mainly staphylococci) and to a lesser extent – gram-negative bacteria.

Pharmacokinetics: Practically not absorbed through intact skin; plasma concentrations of miconazole are minimal after topical application.

Skin and nail infections caused by dermatophytes or fungi of the genus Candida sensitive to miconazole; superinfection caused by gram-positive microorganisms.

Adults and children apply Micogel to the affected skin areas with a thin layer 2 times a day, without rubbing. If necessary, apply an occlusive dressing. The course of treatment depends on the effectiveness of therapy and the results of mycological tests and is 1-6 weeks; the average duration of treatment for candidiasis of the skin is 1-3 weeks, infections caused by dermatophytes – 3-4 weeks, infections with a more protracted course – 5-6 weeks. After the disappearance of clinical symptoms of the disease, the use of Micogel should be continued for at least 1 week. In the treatment of onychomycosis, after preliminary exfoliation of the affected nail plate, the gel is applied with a thin layer to the nail bed 1-2 times a day. The therapy is carried out continuously for at least 3 months until the final formation of a new nail.

Hypersensitivity to miconazole nitrate and/or other components of the drug; skin diseases caused by herpes viruses.

The drug is well tolerated in most cases. The following side effects are possible:

Skin and subcutaneous tissue disorders: application site reactions, including redness, irritation, burning, rash, itching, dry skin; contact dermatitis;

Immune system disorders: hypersensitivity reactions, including urticaria, angioedema, anaphylactic reactions.

Avoid contact with eyes and open wounds.

Use with caution in cases of microcirculation disorders and diabetes.

If your nails are affected, they should be cut as short as possible.

If the feet are affected, it is necessary to carefully treat the spaces between the toes, wear loose, well-ventilated shoes and change socks daily.

If an allergic reaction develops, the drug should be discontinued.

Pregnancy and breastfeeding. External use of the drug during pregnancy is possible, but requires special caution (after consulting a doctor).

When using the drug externally during breastfeeding, it is recommended to stop breastfeeding for the period of treatment.

Children. The medicine can be used in children from birth after consulting a doctor.

There are no reports of the ability to affect the reaction speed when driving vehicles or working with other mechanisms.

It is not recommended to use Micogel simultaneously with other ointment forms. It is noted that when used systemically, miconazole inhibits CYP 3A4/2C9. Due to limited systemic availability, clinically significant interactions are rarely observed when used topically. Accordingly, information about a possible increase in the activity of antidiabetic drugs – sulfonylurea derivatives and phenytoin when used simultaneously with miconazole is not clinically significant.

However, patients taking oral anticoagulants such as warfarin should exercise caution and monitor the prothrombin index.

Due to the lack of systemic absorption, no cases of overdose have been reported. Overdose symptoms may include skin irritation, which usually disappear after discontinuation of treatment.

The product is intended for topical application only and is not for oral use. In case of accidental ingestion of a large amount of the product, an appropriate method of gastric emptying should be used.

In the original packaging at a temperature of 2-8 °C.