Pharmacological properties
Hypromellose is a partially methylated and hydroxypropylated cellulose. Normally, the cornea should be moistened mainly by mucin, which is produced by the conjunctiva. Mucin is adsorbed on the cornea and forms a hydrophilic surface. In dry eye syndrome, especially in the case of mucin deficiency, the use of artificial tear fluid is prescribed.
Hypromellose is particularly suitable for this application due to its surface activity and adsorption capacity. Due to its physicochemical action, hypromellose in aqueous solution reduces surface tension and also increases viscosity. Hypromellose adheres well to the cornea and conjunctiva and ensures normal hydration. The severity of irritation symptoms caused by blinking due to tear fluid deficiency is thus reduced, which prevents the occurrence of symptoms of epithelial drying.
Indication
For the symptomatic treatment of dryness of the cornea and mucous membrane of the eye (dry eye syndrome) caused by impaired tear secretion and tear function due to local or systemic diseases, as well as in case of insufficient or incomplete closure of the eyelids. For wetting and additional hydration of hard contact lenses.
Application
Treatment of dry eye syndrome requires individual dosage. Unless otherwise prescribed, 1 drop is instilled into the conjunctival sac 3-5 or more times a day, depending on the need.
Soft contact lenses should be removed before using Artelac, wait 15 minutes, then reinsert them.
Artelac can also be used to re-wet hard contact lenses.
With prolonged use of the drug Artelac, you should consult a doctor.
Instructions for using the drops. Tilt your head back, pull the lower eyelid down with the index finger of one hand. With the other hand, holding the bottle with the dispenser vertically above the eye (the whole eye), drop 1 drop into the pulled conjunctival sac. Try to move the eyeball without closing the eye so that the liquid spreads well over it.
Contraindication
Hypersensitivity to any of the components of the drug.
Side effects
Hypersensitivity reactions are very rare. Burning, redness, a feeling of a foreign body in the eye, blurred vision, tearing, swelling, itching, pain in the eye may occur. Artelac contains cetrimide as a preservative, which can cause eye irritation, especially with frequent or prolonged use, and can damage the cornea. Thus, for long-term treatment of chronic keratoconjunctivitis sicca, preference should be given to preservative-free drugs.
Special instructions
Wash your hands thoroughly before use. Do not touch your eyes or eyelids with the dropper tip when instilling. Close the bottle immediately after use.
Use during pregnancy and breastfeeding. There is no risk associated with the use of Artelac during pregnancy and breastfeeding, since hypromellose is not absorbed and therefore has no systemic effect.
Children: There are no data on the use of the drug in children.
The ability to influence the reaction speed when driving or operating other mechanisms. Even when used as directed, the drug can cause short-term blurred vision due to the formation of a strip in the field of vision, so when driving or operating other mechanisms, patients should wait until their vision clears.
Interactions
Unknown. It should be noted that when using other local ophthalmic agents, Artelac should always be the last drug to be administered with an interval of about 15 minutes, so that its stay on the surface of the eye, i.e. the moisturizing effect, is not reduced.
Overdose
Unknown and does not require any necessary measures.
Storage conditions
At a temperature not exceeding 30 °C.











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