Metafora film-coated tablets 1000 mg 60 pcs.

• active ingredient: metformin hydrochloride;
• 1 tablet contains metformin hydrochloride 1000 mg, which corresponds to metformin 780 mg;
• excipients: povidone; magnesium stearate; shell: Opadry Clear film coating mixture: hypromellose; polyethylene glycol.

• Hypersensitivity to metformin or to any other component of the drug;
• any type of acute metabolic acidosis (e.g., lactic acidosis, diabetic ketoacidosis);
• diabetic precoma;
• severe renal failure (glomerular filtration rate (GFR) < 30 ml/min);
• acute conditions that occur with a risk of developing kidney dysfunction: dehydration, severe infectious diseases, shock;
• diseases that can lead to the development of tissue hypoxia (especially acute diseases or exacerbation of a chronic disease): decompensated heart failure, respiratory failure, recent myocardial infarction, shock;
• liver failure, acute alcohol poisoning, alcoholism.

The usual starting dose is 500 mg or 850 mg (Metaphora, film-coated tablets, 500 mg or 850 mg) 2-3 times daily with or after meals.

After 10-15 days, the dose should be adjusted according to the results of serum glucose measurements.

Slowly increasing the dose helps reduce side effects from the digestive tract.

Pregnant women

When planning a pregnancy, as well as in the event of pregnancy, it is recommended to use insulin, not metformin, to treat diabetes to maintain blood glucose levels as close to normal as possible, in order to reduce the risk of fetal malformations.

Children

The drug Metafora should be used to treat children aged 10 years and older.

Drivers

Metformin monotherapy does not affect the reaction rate when driving or operating other mechanisms, since the drug does not cause hypoglycemia. However, caution should be exercised when using metformin in combination with other hypoglycemic agents (sulfonylureas, insulin or meglitinides) due to the risk of hypoglycemia.

When using the drug in a dose of 85 g, hypoglycemia was not observed. However, in this case, the development of lactic acidosis was observed. A significant excess of the metformin dose or concomitant risk factors can cause the occurrence of lactic acidosis. Lactic acidosis is an emergency and should be treated in a hospital. The most effective measure for removing lactate and metformin from the body is hemodialysis.

The most common adverse reactions at the beginning of treatment are nausea, vomiting, diarrhea, abdominal pain, and lack of appetite.

Alcohol intoxication is associated with an increased risk of lactic acidosis, especially in the presence of starvation, malnutrition, or liver failure.

Store in the original packaging at a temperature not exceeding 25 °C.

Keep out of reach of children.