PMS-Cholestyramine regular with orange flavor powder for oral suspension 4 g/9 g in 9 g bags 30 pcs.

The active substance is cholestyramine resin, a copolymer of styrene and divinylbenzene with quaternary ammonium functional groups (1 sachet of powder contains cholestyramine resin 4 g).

Excipients: sucrose, anhydrous citric acid, anhydrous colloidal silicon dioxide, sunset yellow FCF dye (E 110), D&C yellow No. 10 dye (quinoline yellow E 104), D&C yellow No. 10 aluminum lake dye 15% (quinoline yellow E 104), propylene glycol alginate, orange flavoring, containing: orange flavoring, maltodextrin, acacia (gum arabic E 414), butylhydroxytoluene (E 321).

• with complete obstruction of the biliary tract, when bile does not enter the intestines at all;
• in case of hypersensitivity to the active substance or other components included in the preparation.

Cholestyramine should be administered orally.

In order to minimize possible side effects from the gastrointestinal tract, it is advisable to start therapy with one dose of the drug once a day. Then, after 1-2 days, the dosage can be increased.

It is important to motivate the patient to adhere to the prescribed treatment regimen, despite the side effects that occur from the gastrointestinal tract. Monitoring compliance with the drug regimen plays an important role for successful treatment.

The recommended dose for adults is 4 g of cholestyramine 1 to 6 times daily. The dosage can be adjusted to better meet the individual needs of the patient.

The drug should not be taken in dry form, it is intended only for use in the form of an aqueous suspension.

Preparation of the drug for administration: the color of the drug may vary from batch to batch, but does not affect the quality of the product itself.

To prepare the suspension, place the contents of one sachet in a glass of 120-180 ml of water or a non-carbonated drink (milk or fruit juice). After one minute, stir the powder vigorously into the liquid. The powder can be stirred into soup or juice with pulp squeezed from fruit (apples or pineapples).

Pregnant women

Since cholestyramine is not absorbed in the intestine, it is theoretically unlikely to have any adverse effects on the fetus when taken at recommended doses. However, there have been no controlled clinical studies of the drug in pregnant women. In addition, cholestyramine may interfere with the absorption of fat-soluble vitamins in the intestine, which may adversely affect fetal development.

The drug should be used with caution in breastfeeding women, as it may interfere with the absorption of vitamins in the intestines, which may lead to malnutrition in the child.

Thus, the use of the drug in pregnant and breastfeeding women is possible only in cases where the potential benefit from using the drug outweighs the potential risk to the fetus or child.

Children

The safety and effectiveness of cholestyramine in children have not been established.

Drivers

There is no data on the effect of the drug on the reaction speed when driving vehicles or other mechanisms, but the possibility of developing adverse reactions from the nervous system, such as dizziness, drowsiness, and loss of consciousness, should be taken into account.

One case of overdose was described in a patient who took the drug for several weeks in a dose that was 150% of the maximum recommended daily dose. No significant events were noted. The main consequence of overdose may be impaired gastrointestinal tract patency. The presence of such obstruction, the degree of its severity and the necessary symptomatic therapy are determined.

Constipation is the most common side effect of cholestyramine, especially at high doses and in elderly patients (over 60 years of age). In most cases, these side effects are relieved by standard therapy. In some cases, a temporary dose reduction or discontinuation of the drug may be necessary.

Store at a temperature not exceeding 30 °C, in a dry place and out of the reach of children.

Shelf life – 3 years.