Ultrafastin gel 2.5% tube 50 g

Pharmacodynamics. Ketoprofen has anti-inflammatory and analgesic effects. Ketoprofen inhibits the activity of COX-1 and COX-2, resulting in a decrease in the synthesis of prostaglandins, which play a major role in the pathogenesis of inflammation and pain. The mechanism of anti-inflammatory action of ketoprofen is incompletely understood. It reduces oxygen metabolism of neutrophils and the release of lysosomal enzymes, inhibits macrophage migration and exhibits anti-bradykinin activity. Properties of this type allow to shorten the II phase of the inflammatory reaction by reducing the migration of macrophages and granulocytes into the synovial membrane and the formation of cellular filtrates.

Pharmacokinetics. Ketoprofen penetrates well through the skin and has a local anti-inflammatory and analgesic effect. Absorption and distribution depend on the thickness of the skin, subcutaneous tissue and its blood supply, as well as on the size of the inflammatory infiltrate. After external application, the concentration of ketoprofen at the site of application is similar to that when applied internally, and the concentration in the blood plasma is 60 times lower. The bioavailability of the gel is about 5%. Almost 99% of the absorbed ketoprofen binds to blood plasma proteins. The drug is metabolized in the liver. About 80% of the dose is excreted in the urine in the form of metabolites, 10% in unchanged form. Does not accumulate in the body.

It is used topically as an analgesic and anti-inflammatory drug for post-traumatic pain in muscles and joints, and inflammation of tendons.

For external use. 2-3 times a day, apply a small amount of gel (3-5 cm) to the skin in the painful area and rub in lightly. The duration of treatment is determined by the doctor.

There is no need to apply a dry bandage, as the gel is well absorbed through the skin, has no odor, does not contain dyes, does not leave greasy stains, and does not stain clothes.

Hypersensitivity to ketoprofen and/or other components of the drug; hypersensitivity to other nonsteroidal anti-inflammatory drugs; weeping dermatoses, eczema, infected abrasions, wounds, burns, infectious skin lesions.

Do not use in the third trimester of pregnancy.

Do not use in children under 15 years of age.

Side effects after using ketoprofen occur rarely. These are allergic skin reactions, skin hyperemia, photosensitization, skin rash, purpura. Very rarely, hypersensitivity to light and side effects with a more severe course of the disease are possible – papular eczema with the likelihood of relapse.

Ketoprofen may cause bronchospasm in patients sensitive to acetylsalicylic acid and other nonsteroidal anti-inflammatory drugs.

Depending on the amount of gel applied to the skin, the area of ​​the treated area, the duration of treatment, the use of the bandage may cause other side effects, for example, from the gastrointestinal tract or kidneys.

Do not allow the drug to come into contact with mucous membranes and eyes.

Do not use on damaged areas of skin.

During prolonged use in patients with severe liver and/or kidney failure, caution should be exercised. In the event of a rash, treatment should be discontinued and appropriate therapy should be administered. During treatment and for 2 weeks after its completion, sun exposure and solarium use should be avoided.

If skin changes occur at the site of application, treatment should be discontinued.

Pregnancy and breastfeeding. In the I and II trimesters of pregnancy, the drug can be used only when the potential benefit to the mother outweighs the risk of negative effects on the fetus. In the III trimester of pregnancy, the use of the drug is contraindicated.

It is not recommended to use the drug during breastfeeding.

The effect of the drug on the ability to drive vehicles and perform work that requires concentration. No data.

With prolonged use, symptoms of interaction with other drugs may appear, the same as with systemic use.

Concomitant use with oral anticoagulants, heparin, thrombolytics, antiplatelet agents, cefoperazone, cefamandole increases the risk of bleeding. Ketoprofen reduces the effect of antihypertensive drugs and diuretics. Enhances the effect of insulin and oral drugs (dose adjustment is required). Concomitant use with sodium valproate causes platelet aggregation disorders. Increases the concentration of verapamil and nifedipine in blood plasma. Ketoprofen enhances the effect of methotrexate. Cannot be used together with acetylsalicylic acid and its derivatives. Ketoprofen enhances the effect of alcohol and the side effects of other nonsteroidal anti-inflammatory drugs.

There are no data on overdose of the drug when used externally.

In a dry place, protected from light, at a temperature of 15-25 °C.