Ketorol Express tablets, orally dispersible, 10 mg, blister pack of 10 pcs.

Active ingredient: ketorolac tromethamine;

1 tablet contains ketorolac tromethamine 10 mg;

Excipients: microcrystalline cellulose, silicon dioxide, butylhydroxyanisole (E 320), mannitol (E 421), crospovidone, sucralose, magnesium stearate, dye (Lake Of Quinoline Yellow WS), flavoring (Spearmint Flavor).

• Hypersensitivity to ketorolac or to any component of the drug;
• patients with active peptic ulcer disease, recent gastrointestinal bleeding or perforation, or a history of peptic ulcer disease or gastrointestinal bleeding;
• bronchial asthma, rhinitis, angioedema or urticaria caused by the use of acetylsalicylic acid or other NSAIDs (due to the possibility of severe anaphylactic reactions);
• history of bronchial asthma;
• do not use as an analgesic before and during surgery and after manipulations on the coronary vessels;
• severe heart failure;
• nasal polyposis with complete or partial obstruction, angioedema or bronchospasm;
• do not use in patients who have had surgery with a high risk of hemorrhage or incomplete bleeding and in patients receiving anticoagulants, including low doses of heparin (2500-5000 units every 12 hours);
• hepatic or moderate/severe renal failure (serum creatinine clearance more than 160 μmol/l);
• Ketorolac is contraindicated during labor and delivery because, as a result of its inhibitory effect on prostaglandin synthesis, it can negatively affect fetal blood circulation and suppress uterine contractions, thereby increasing the risk of uterine bleeding;
• suspected or confirmed cerebrovascular bleeding, hemorrhagic diathesis, including blood clotting disorders and high risk of bleeding;
• simultaneous treatment with other non-steroidal anti-inflammatory drugs (including selective cyclooxygenase inhibitors), acetylsalicylic acid, warfarin, pentoxifylline, probenecid or lithium salts;
• hypovolemia, dehydration;
• risk of kidney failure due to fluid depletion.

Ketorol Express in the form of tablets that disperse in the oral cavity should be taken only with dry hands.

The tablet should be placed on the tongue, where it will immediately begin to dissolve. Hold in the mouth for a few seconds until it is completely dissolved, if desired, you can drink water.

Taking tablets that disperse in the oral cavity does not require mandatory washing down with water, does not affect saliva production, and allows the drug to be taken by patients with abnormalities in the act of swallowing due to behavioral or neurological disorders.

To prevent indigestion, it is advisable to take the drug during or after a meal (main meal or snack) or with antacids.

Pregnant women

Contraindicated.

Children

Do not use in children under 16 years of age.

Drivers

Some patients may experience dizziness, drowsiness, visual disturbances, headache, vertigo, insomnia, or depression when taking ketorolac. If patients experience these or other similar side effects, they should not drive or operate machinery.

Symptoms following acute NSAID overdose are usually limited to lethargy, drowsiness, nausea, vomiting and epigastric pain, which are usually reversible with supportive treatment. Gastrointestinal bleeding may occur. Rarely, hypertension, acute renal failure, respiratory depression and coma may occur. Anaphylactoid reactions have been reported with therapeutic doses of NSAIDs and may occur after overdose.

Gastrointestinal (GI) disorders, including: heartburn, stomatitis, nausea, vomiting, abdominal pain, dyspepsia, constipation/diarrhea, flatulence, feeling of fullness, gastrointestinal (stomach/duodenal) ulcers, major bleeding/perforation <> <> Other disorders: renal impairment, dizziness, drowsiness, anemia, edema, increased liver enzymes, headaches, hypertension, increased bleeding time, pain at the injection site, itching, purpura, rash, tinnitus, sweating.

Ketorolac is extensively bound to plasma proteins (average 99.2%). There is no evidence from animal or human studies that ketorolac tromethamine induces or inhibits hepatic enzymes that metabolize it or other drugs.

Isolated cases of seizures have been reported during concomitant use of ketorolac tromethamine and anticonvulsants (phenytoin, carbamazepine).

Store in the original packaging at a temperature not exceeding 25 °C.

Keep out of reach of children.

Shelf life – 2 years.