Pantestin Darnitsa gel tube 30 g

Pharmacodynamic parameters. Pantestin Darnytsia gel contains two pharmaceutical active ingredients: dexpanthenol and miramistin.

Dexpanthenol – an indispensable component of a normally functioning epithelium – is a biologically active stable form of pantothenic acid.

Dexpanthenol is easily converted into pantothenic acid, which increases the content of reduced glutathione in cells (antioxidant effect), promotes ATP synthesis, and is also part of coenzyme A (CoA). Molecules of CoA and ATP are involved in the synthesis of fatty acids, phospholipids and cholesterol, necessary for the restoration of cell membranes. In addition, CoA is involved in protein metabolism reactions of epithelial cells.

In vitro studies have established the effect of dexpanthenol on human fibroblasts – increasing their proliferation, migration and adhesion processes, and collagen synthesis.

Due to good penetration through the skin and high local concentrations, dexpanthenol is widely used to stimulate epithelization processes, granulation of damaged skin and reduce itching.

In addition, dexpanthenol improves barrier properties, hydration of the stratum corneum, reduces transepidermal water loss, maintaining softness and elasticity of the skin, and also has anti-inflammatory properties.

In order to prevent infection of wounds that do not heal for a long time and to treat wound infection, the effect of the drug is supplemented with the antiseptic miramistin.

Surfactant of the cationic miramistin type due to interaction with the lipids of the outer membrane of the microorganism has a destructive effect on the causative agents of wound infection. Cocci that are highly sensitive to the substance (primarily staphylococci, as well as streptococci, including pneumococci). Miramistin is also effective against gram-negative pathogens. The activity of miramistin is aimed at microorganisms of both aerobic and anaerobic types, non-spore-forming and spore-forming; including microbial associations and hospital microflora with multiple resistance to antibiotics (increases the sensitivity of microbes to the specified drugs). Inhibits the formation and growth of biofilms of Staphylococcus aureus and Streptococcus pyogenes (group A). Miramistin also effectively affects large viruses (including herpes), dermatophytes, ascomycetes, yeast and yeast-like fungi.

Due to the pronounced HYPEROSMOLAR effect in the wound and adjacent tissues, the use of miramistin helps to inhibit the inflammatory process.

The local effects of miramistin are complemented by stimulation of the restoration of damaged tissues when it is used, including in the case of wounds that do not heal for a long time.

Pharmacokinetic parameters. With local application, dexpanthenol is quickly absorbed, being metabolized in the tissues into pantothenic acid.

It is unlikely that miramistin enters the systemic bloodstream, the substance affects microorganisms in the wound area and adjacent tissues.

• Treatment and prevention of infection of minor wounds, burns, cuts and scratches; skin infections (including secondary infected neurodermatitis and eczema); wounds of various etiology and location (including postoperative, decubitus and trophic ulcers in the proliferative phase); sunburn; treatment of granulating burn wounds and their preparation for autodermoplasty, improvement of engraftment of skin grafts; periodontal diseases (gingivitis – catarrhal or ulcer-necrotic forms; periodontitis – focal or widespread), diseases or traumatic lesions of the mucous membrane of the oral cavity (stomatitis, including aphthous, chronic, recurrent); erosion of the cervix, erosive colpitis and damage to the mucous membrane of the vagina; treatment and prevention of diaper rash and diaper dermatitis infection; prevention of radiation damage to the skin, mucous membranes, treatment of radiation ulcers (in the proliferative phase).

Locally. distributed in a thin layer on the surface of the wound after its standard treatment. then a sterile gauze bandage is applied. as an option – apply the gel to the dressing material, and then to the surface of the wound.

In the presence of wound exudate, before applying the gel, the wound is treated with an antiseptic and dried with a sterile napkin.

In case of damage to the skin and sunburn, the drug is applied to the affected areas.

Gynecological pathology: tampons impregnated with the drug are inserted in the lying position deep into the vagina.

In the treatment of diseases of the oral cavity, the drug is used only in adults. After cleaning the oral cavity, the gel is distributed in a thin layer on the affected area. Do not consume liquid or food for 1 hour. In the treatment of manifestations of prosthetic stomatitis, dentures can be used after applying the gel.

Apply 2-3 times a day for 7-10 days (until the affected area is completely healed or the intensity of inflammation decreases).

Hypersensitivity to the active pharmaceutical ingredients of the drug or its other components.

• Hypersensitivity reactions (as a rule, with individual intolerance, itching of the skin, rashes, hyperemia of various degrees of severity are noted); rarely – a short-term (disappears spontaneously within 15-20 seconds) burning sensation; dermatitis (contact or allergic), erythema, eczema, urticaria, irritation, swelling, dryness or wetting of the skin.

Protect the eyes from contact with the gel.

Do not use the drug in case of pronounced purulent exudation from the wound.

The duration of treatment is determined by the doctor individually.

During pregnancy and breastfeeding, the gel can be used after consulting a doctor (avoid application to large areas of skin).

Used in children from the first days of life.

There is no influence on the speed of reaction when driving vehicles or other mechanisms.

The antimicrobial effect of miramistin is inactivated by:

• surfactants of the anionic type (soap solutions);
• other antiseptics.

Simultaneous use of miramistin:

• with antibiotics (systemic or local) – increases the sensitivity of microorganisms to them;
• with muscle relaxants of depolarizing action – increases their effectiveness;
• with muscle relaxants of non-depolarizing action – reduces their effectiveness.

With local application unlikely. in case of accidental ingestion of the gel, symptomatic treatment is carried out.

At a temperature ≤25 °C in the original packaging. do not expose to freezing.