Heparin Darnytsia gel 600 IU/g tube of 30 g

Composition and form of release

Composition

active substance: heparin;

1 g of gel contains sodium heparin 600 IU;

auxiliary substances: carbomer, tromethamine, propylene glycol, benzyl alcohol, purified water.

Release form

Gel.

Pharmacological properties

Pharmacodynamics.

Sodium heparin – a direct anticoagulant – blocks the biosynthesis of thrombin, inhibits the formation of fibrin from fibrinogen, reduces platelet aggregation and inhibits the activity of hyaluronidase. when applied topically, heparin-Darnytsia gel exhibits antithrombotic, anti-inflammatory and anti-edematous effects. the drug does not have a local irritant effect.

Pharmacokinetics.

When applied to the skin, a small amount of sodium heparin, which is mainly excreted by the kidneys, enters the systemic bloodstream.

Indication

Treatment of diseases of superficial veins, such as varicose veins and related complications, phlebothrombosis, thrombophlebitis, superficial periphlebitis. postoperative varicose phlebitis, complications after surgical removal of the subcutaneous vein of the lower limb. injuries and blows, infiltrates and localized swellings, subcutaneous hematomas. injuries and stretching of muscle-tendon and capsuloligamentous structures.

Application

The drug heparin-Darnytsia is used locally, 3-10 cm of gel is applied with light rubbing movements to the skin of the affected area 1-3 times a day. the dose of the drug depends on the area of ​​the affected area. the duration of treatment is determined by the doctor individually, taking into account the severity of the course of the disease.

Contraindication

Individual hypersensitivity to heparin or any component of the drug, trophic ulcers of the lower extremities, bleeding and / or infected wounds, hemorrhagic diathesis, purpura, thrombocytopenia, hemophilia. tendency to bleeding.

Side effects

Dermatological disorders: swelling of the skin, rash, itching, redness, swelling, burning sensation, hemorrhages, sometimes – the appearance of small pustules, blisters or blisters, which quickly disappear after stopping the use of the drug.

From the side of the immune system: hypersensitivity reactions, including urticaria, angioedema.

When applied to large areas of the skin, the development of systemic adverse reactions is possible.

Special instructions

Heparin-Darnytsia gel should not be applied to open wounds and should not be used in the presence of purulent processes!

Do not use on large areas of skin, on areas of skin with increased sensitivity, on mucous membranes. Do not allow the gel to get into the eyes.

It is recommended to monitor blood coagulation parameters under the supervision of a doctor.

In case of blood coagulation disorders, the gel is not recommended to be applied to large areas of the skin.

The drug should not be prescribed for bleeding.

The drug should be used with caution in hemorrhagic processes.

In the case of phlebitis treatment, the drug should not be rubbed into the skin.

Use during pregnancy and breastfeeding

Not used.

Children

Given the limited experience of use, the drug should not be prescribed to children.

The ability to influence the speed of reactions when driving vehicles or other mechanisms
Does not affect.

Interactions

Oral anticoagulants – simultaneous use with heparin-Darnytsia gel can cause prolongation of prothrombin time.

NSAIDs, venotonic drugs – with simultaneous use, the effect of Heparin-Darnytsia gel increases.

Medicines for external use (for example, NSAIDs) – when used simultaneously with Heparin-Darnytsia gel, the absorption of other medicines through the skin is significantly increased.

The drug should not be used together with drugs for local use, for example, with drugs containing tetracycline, hydrocortisone, salicylic acid, with anticoagulants.

Overdose

With local application – unlikely. due to the lack of information on accidental overdose or ingestion of the drug, there are no specific recommendations for these conditions.

Treatment: General supportive measures may be administered.

As a result of accidental oral use of the gel, the child may experience nausea or vomiting. In this case, the stomach should be washed, and if necessary, symptomatic therapy should be prescribed. The effect of heparin can be neutralized with protamine sulfate.

Storage conditions

In the original packaging at a temperature not higher than 25°C.