Structum hard capsules 500 mg 60 pcs

Pharmacological properties

Pharmacodynamics. Chondroitin sulfate is an important component of bones and cartilage tissue of the joints, which helps maintain the integrity of the cartilage matrix due to:

increasing the anabolic activity of chondrocytes (stimulation of proteoglycan synthesis);
inhibiting the adverse effects of interleukin-1β on the cartilage matrix;
preventing excessive degradation of the cartilage matrix (by inhibiting elastase in tissues, as well as by reducing the activity of metalloproteases, such as stromelysin and collagenase, in parallel with increasing the activity of the tissue inhibitor of metalloproteases, blocking these enzymes).
Chondroitin sulfate also improves the homeostasis of the synovial environment of the joints by stimulating the synthesis of hyaluronic acid, thus contributing to the maintenance of proper viscosity of the synovial fluid. Due to the enzymatic and anti-free radical properties of chondroitin sulfate, it inhibits the development of inflammatory reactions.

Pharmacokinetics. After oral administration of chondroitin sulfate, it is absorbed in the gastrointestinal tract, C max in blood plasma is reached after 4 hours.

The drug accumulates mainly in synovial fluid. It is excreted mainly with feces.

Indications

Additional therapy for degenerative diseases of the joints and spine – osteoarthritis, intervertebral osteochondrosis.

Application

Capsules are swallowed whole, washed down with 250 ml of water.

Adults and children over 15 years of age take 1 capsule (500 mg) 2 times a day (daily dose – 1 g). Duration of treatment – 3-6 months.

Contraindications

Allergic reactions in history to any components of the drug.

Side effects

From the skin and subcutaneous tissues: infrequently – erythema, urticaria, eczema, maculopapular rash (with or without itching) and / or edema;

From the gastrointestinal tract: rarely – nausea, vomiting;

From the immune system: rarely – angioedema (Quincke’s edema).

Special instructions

Pregnancy and breastfeeding. Since relevant studies have not been conducted, the drug is not recommended for use during this period.

Children. The drug is contraindicated in children under 15 years of age.

Does not affect the speed of reaction when driving or working with other mechanisms.

Interactions

Not described.

Overdose

Treatment is symptomatic.

Storage conditions

At a temperature not exceeding 25 °C.