Detralex film-coated tablets of 1000 mg 30 pcs

Detralex is a French original drug with a strong pharmacological effect, which is used for the treatment of vein diseases.

The medicinal product is registered on the territory of Ukraine and has a dual effect:

1. Venotonic — increases the tone of vessel walls due to increased cell contraction in smooth muscles. The elasticity and ability of veins to maintain pressure inside the vessels increases, reduces distensibility.
2. Angioprotective — improves the transport of substances to capillaries, normalizes metabolism, reduces permeability and strengthens vessel walls.

The drug prevents lymph stagnation and increases blood supply to tissues.

Reduces the symptoms of inflammation by stopping the formation of substances that trigger the inflammatory reaction mechanism in the blood vessels and cause painful sensations in the legs.

The drug “Detralex” and its analogues are produced in the form of tablets, which are covered with a protective film shell. The composition of the medicine includes a combination of plant bioflavonoids (diosmin and hesperidin), which is obtained by a high degree of purification and reduction of the components of the drug to the smallest particles (microns). The process accelerates the release of active substances and the onset of a therapeutic effect.

Pharmacodynamics

“Detralex” has angioprotective and venotonic properties. It normalizes the work of the venous system, helps to reduce the permeability of blood vessels, improves the elasticity of veins and the ability to withstand intravascular pressure. Beneficially affects the outflow of lymph, improving lymphatic drainage. The angioprotective action consists in normalizing the microcirculation of blood vessels, blood supply and tissue metabolism. It increases the tone of the veins, reduces the adhesion of leukocytes in the venules, as a result of which the inflammation on the walls and leaflets of the vein valves decreases. The drug “Detralex” is active in the treatment of chronic venous insufficiency of the lower extremities, as well as in the treatment of hemorrhoids. 

Pharmacokinetics

The components of the drug leave the body mainly through the intestines with feces. Approximately 14% of the dose is excreted in the urine. The elimination half-life is 11 hours. The components of the drug are actively metabolized with the formation of phenolic acids in the urine. 

The medicine “Detralex” is prescribed to relieve and eliminate the symptoms of diseases in which there is a violation of the tone of blood vessels:

• with varicose veins, accompanied by a pain syndrome caused by cramps in the lower limbs that occur at night, a feeling of fatigue, in the morning, heaviness and swelling in the legs;
• to ease the course of acute and chronic hemorrhoids.

It is used to treat the phenomena of chronic venous insufficiency of the lower extremities, which complicates the outflow of lymph:

• with trophic changes of the skin;
• trophic ulcers of veins;
• swelling in the lower extremities.

Contraindications to prescribing the drug are:

• increased individual sensitivity to active or auxiliary substances included in the dosage form;
• the instructions for use do not contain data on taking the drug for children.

Tablets for veins “Detralex” are prescribed to adults only internally, depending on the severity and nature of the disease:

1. In the treatment of venous insufficiency and varicose veins, patients are recommended to take twice: 1 tablet in the morning and 1 tablet in the evening. The drug is used during meals, washed down with water. After a week, they switch to a single dose: 2 pills in the morning.
2. In the treatment of acute hemorrhoids, take up to 6 tablets per day for 4 days without fasting. Then switch to the scheme: 2 pills in the morning and 2 in the evening.

Duration of reception is 3 days. The maintenance dose is 2 tablets per day. The course of treatment is 2-3 months under the supervision of a doctor.

With acute hemorrhoids, Detralex does not replace specific therapy. Its reception does not interfere with the treatment of other proctological pathologies. If, after the completion of a short course of treatment, the persistence of symptoms or insufficient effectiveness of the drug is noted, it is necessary to conduct a proctological examination and review the treatment tactics. 

In the treatment of venous outflow disorders, taking “Detralex” should be supplemented with the following recommendations to improve the therapeutic effect:

• try to reduce excessive body weight, if any;
• avoid prolonged exposure to the sun;
• do not stay on your feet for a long time;
• take short walks;
• wear compression underwear to improve blood circulation. 

There are no data on the use of the drug “Detralex” for the treatment of children.

During pregnancy, a woman’s body weight increases, which leads to an increase in the load on the veins in the lower extremities. There is a feeling of heaviness in the legs, swelling appears. The effectiveness of the harmful effect of the medicinal product on the fetus was not revealed. The drug can be prescribed with caution in the 3rd trimester of pregnancy after consulting a doctor. 

It is not known about the ability of the active substance of the drug and its metabolites to penetrate into breast milk. In this regard, the risk to the health of newborn babies cannot be ruled out. The decision to continue or stop breastfeeding during the period of taking the medicine is made after assessing the potential benefits of treatment and the benefits of natural breastfeeding for the child. 

Animal studies have not revealed toxic effects on fertility and reproductive function. 

The negative impact on the ability to drive a motor vehicle and work with complex mechanisms, which requires the speed of psychomotor reactions and increased attention, is insignificant or absent. However, taking into account the possible development of adverse reactions on the part of the autonomic nervous system, one should be careful when they occur. 

Data on overdose are limited. Most often, overdose reactions from the gastrointestinal tract were reported: abdominal pain, nausea, diarrhea. Rashes and itching may occur on the skin. 

Treatment is symptomatic. 

Usually the drug is well tolerated.

Side effects from the gastrointestinal tract are possible, but expressed weakly (nausea, upset, pain and discomfort in the stomach).

Sometimes there are reactions from the autonomic nervous system: light dizziness, weakness, headache or itching, rash on the skin.

Both cases do not require cancellation of the application.

It is not allowed to take the drug during breastfeeding, as there is no data on the interaction of active substances with mother’s milk.

“Detralex” does not lower or raise blood pressure.

A study on the interaction of Detralex with other drugs was not conducted. Until now, clinically significant interactions with other substances and drugs are unknown. 

The drug does not require special storage temperature conditions. It is necessary to protect from children. Shelf life – 4 years.

“Detralex”: how to take the drug?

“Detralex” in the treatment of leg swelling is taken 2 times a day. Medicines are taken according to the scheme: 1 tablet in the morning and 1 in the evening after a meal. The drug is washed down with water at room temperature.

How to take “Detralex” for hemorrhoids?

To reduce acute symptoms and relieve symptoms of hemorrhoids, the drug is taken 2 tablets in the morning, afternoon and evening on an empty stomach. The daily dose is 6 tablets. The course is 4 days.

How to use Detralex 1000 for varicose veins?

“Detralex” is available in tablets containing 500 and 1000 mg of the active substance. The difference lies in the amount of diosmin and hesperidin in one tablet (450 and 50 mg in the first case, 900 and 100 mg in the second) and the number of tablets in the package (60 and 30 pieces). In pharmacies, the drug is available in two dosage forms, the price of which differs slightly.

The frequency of taking Detralex 1000 is halved. For the treatment of varicose veins, 1 tablet is used once after a meal.

“Detralex”. How long to take the drug?

The duration of treatment depends on the course of the disease and is usually 2-3 months under the supervision of a doctor.