Pimafucin vaginal suppositories 100 mg strip 3 pcs

Pharmacological properties

Pharmacodynamics. natamycin is a broad-spectrum polyene antibiotic active against pathogenic fungi, including yeast fungi and especially candida albicans, which are most often the cause of genital tract infections. acts fungicidally, binding sterols of cell membranes, disrupting their integrity, causing the death of microorganisms.

The drug does not show sensitizing activity. No cases of allergy to natamycin were detected during treatment or during its industrial production, and no development of resistance to it was noted.

Due to the enteric coating, the tablet acts only in the intestines.

The drug acts quickly and effectively in case of yeast infection of the vagina (candidiasis). Vaginal suppositories have a therapeutic effect also in the presence of discharge from the vagina, inflammatory process and itching, finishing with the upper, less accessible parts of the vagina. The drug quickly melts in the vagina, forming a foamy mass that promotes uniform and complete distribution of the active substance over its entire surface.

Pharmacokinetics. When taken orally in the form of tablets, natamycin is practically not absorbed in the gastrointestinal tract.

Existing methods failed to detect intravaginally administered natamycin and its derivatives in the blood and body fluids, which indicates the absence of a systemic effect of the drug.

Natamycin is active when applied topically and is not absorbed through the skin and mucous membranes.

Indication

Tablets: fungal diseases of the intestines; vaginal suppositories: vaginitis caused by candida albicans; cream: fungal skin lesions caused by candida albicans.

Application

Tablets. for the treatment of intestinal candidiasis, adults are prescribed 1 tablet 4 times a day. usually the therapy lasts 1 week.

Children aged 3 years and older are prescribed 1 tablet 2 times a day. Taking into account the peculiarities of the pharmacodynamic and pharmacokinetic properties of natamycin, the same dose is recommended for children of different ages. Usually, the duration of treatment is 1 week.

Suppositories. Adult women use 1 suppository for 3-6 days. Suppositories are recommended to be inserted as deeply as possible into the vagina (in a lying position) once a day (at night). If it is necessary to carry out treatment for several days, the course of therapy should be completed before the start of menstruation or start treatment after it ends.

The cream is applied to the affected areas of the skin 1-4 times a day, every day. The duration of therapy is usually 2-3 weeks.

Contraindication

Increased sensitivity to the components of the drug.

Side effects

pills

From the gastrointestinal tract: nausea and diarrhea are possible (which occur in the first days of use and disappear on their own during treatment).

Hypersensitivity reactions are possible.

Suppositories. Rarely (0.01%, 0.1%)

Skin and subcutaneous tissue: hypersensitivity reaction, burning sensation and irritation.

Hypersensitivity reactions: some irritation or burning sensation may occur at the application site. If they persist, this may be the result of increased sensitivity to preservatives (parahydroxybenzoates). The presence of methyl parahydroxybenzoate and propyl parahydroxybenzoate in the composition of the drug can cause allergic reactions (possibly delayed).

Special instructions

The use of natamycin in the form of tablets may be associated with the development of an acute attack of porphyria, therefore, the use of the drug is considered dangerous for patients with this disease.

Since the drug in the form of tablets contains lactose, it should not be used in patients with rare hereditary forms of galactose intolerance, lactase deficiency or glucose-galactose malabsorption syndrome.

The drug contains sucrose, which should be taken into account by patients with diabetes. Since the drug contains sucrose, it should not be used in patients with rare hereditary diseases such as fructose intolerance or sucrase-isomaltase deficiency.

During menstruation, treatment with the drug Pimafucin in the form of vaginal suppositories should be interrupted. There is no need to avoid sexual contact during drug therapy.

The period of pregnancy and breastfeeding. Pimafucin can be prescribed during pregnancy and breastfeeding.

Children. Natamycin in the form of coated tablets is used in children older than 3 years; in the form of a cream – in children of all age groups; in the form of vaginal suppositories – they are not used in children.

The ability to influence the speed of reaction when driving a motor vehicle or working with other mechanisms. Does not affect.

Interactions

Not described.

Overdose

There are no messages. when using vaginal suppositories, systemic effects are practically excluded, since the drug is not absorbed through the mucous membrane.

Storage conditions

At a temperature not higher than 25 °C.