Alkodez IC tablets 0.5 g blister 4 pcs.

Anti-alcohol, detoxification, hepatoprotective agent. Activates liver enzymes involved in ethanol metabolism, which helps accelerate the process of removing ethanol and acetaldehyde from the body, reducing their toxic effects. Increases the resistance of hepatocytes to lipid peroxidation products induced by the effects of various toxic agents, in particular ethanol. Prevents the accumulation of fats in hepatocytes, which prevents the formation of fatty infiltration of the liver. Prevents the formation of fibronectin and collagen, inhibits the development of liver cirrhosis.

Activates choline and GABAergic neurotransmitter systems, resulting in improved thinking and short-term memory functions. Prevents the occurrence of motor excitement caused by ethanol. Has a nonspecific, antidepressant and anxiolytic effect, reduces craving for alcohol. Reduces the time of cessation of withdrawal syndrome, reduces mental and somatic manifestations of hangover syndrome.

Metadoxine is rapidly absorbed in the gastrointestinal tract, has high bioavailability (60-80%). Binding to blood plasma proteins is approximately 50%. Metabolized in the liver with the formation of active metabolites – pyridine and pyrrolidone carboxylate. T½ of metadoxine when taken orally or parenterally is 40-60 min. 45-50% of metadoxine is excreted in the urine within 24 hours, 35-50% – with feces within 96 hours.

Reducing the toxic effects of alcohol. Acute alcohol intoxication (mild and moderate). Alcohol withdrawal syndrome. Chronic alcoholism. Complex therapy of liver diseases, especially of alcoholic etiology.

The drug is prescribed to adults orally.

To reduce the toxic effects of alcohol: 2 tablets 30-60 minutes before drinking alcohol or 1 tablet 30-60 minutes before drinking alcohol and 1 tablet within 30 minutes after drinking alcohol.

In case of acute alcohol intoxication of mild and moderate degree, alcohol withdrawal syndrome – 1 tablet 2 times a day 15-30 minutes before meals, the dose can be increased to 3 tablets per day. The course of therapy is 3-7 days, depending on the patient’s condition.

In complex therapy of liver diseases and chronic alcoholism: 1 tablet 2 times a day 15-30 minutes before meals. The maximum daily dose is 3 tablets. The course of therapy is at least 90 days.

Hypersensitivity to any of the components of the drug.

Allergic reactions.

Metadoxine reduces the therapeutic effect of levodopa, so it should be used with caution in Parkinson’s disease on the background of levodopa therapy.

In cases of severe alcohol intoxication, accompanied by loss of consciousness, uncontrollable vomiting, etc., oral administration of medications is inappropriate.

The drug is not used during pregnancy and breastfeeding.

Should not be used in children due to lack of experience in this age group.

Does not affect the reaction speed when driving vehicles or working with other mechanisms.

When used together with levodopa, metadoxine, due to increased decarboxylation of levodopa, reduces its therapeutic efficacy.

No overdose of metadoxine has been reported.

In the original packaging at a temperature not exceeding 25°C.