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Antral belongs to the group of hepatoprotective drugs. It is effective in the treatment of acute and chronic hepatitis of various genesis, cirrhosis of the liver, helps to reduce asthenovegetative disorders, improves appetite, sleep, reduces dyspeptic phenomena.
Antral belongs to the group of hepatoprotective drugs. It is effective in the treatment of acute and chronic hepatitis of various genesis, cirrhosis of the liver, helps to reduce asthenovegetative disorders, improves appetite, sleep, reduces dyspeptic phenomena. When used in courses, the drug normalizes the content of bilirubin, γ-globulins, cholesterol in the blood, prothrombin index, transaminase activity (ALT and AST) and alkaline phosphatase. Antral has prolonged anti-inflammatory, analgesic effects. According to the results of preclinical studies, it was found that Antral in conditions of acute, subacute and chronic liver damage by various xenobiotics and their combinations helps to weaken the effects of hepatotoxins, activate reparative processes in hepatocytes and practically normalize the indicators of the structural and functional state of the liver. The drug inhibits lipid peroxidation processes in the blood and tissues, supports the activity of the body’s antioxidant systems, stabilizes the structure of the liver and hepatocyte membranes. Being a relatively harmless pharmacological agent, Antral does not disrupt the functions of organs and body systems, it has no cumulative properties, immunotoxic, locally irritating, allergenic, ulcerogenic, embryotoxic, teratogenic effects.
The maximum accumulation of the drug in the blood is observed after 3-4 hours, the half-life is 4-5 hours. The drug is excreted in the urine and feces.
active ingredient: 1 tablet contains antral in terms of dry matter 200 mg (0.2 g);
excipients: heavy magnesium carbonate, potato starch, crospovidone, microcrystalline cellulose, povidone, polysorbate, colloidal anhydrous silicon dioxide, calcium stearate, Opadry II 85 G18490 white, Opadry II 85 G25557 red.
Antral is indicated for adults and children for the treatment of: acute and chronic hepatitis of various genesis (viral, alcoholic, drug-induced, toxic); fatty dystrophy and cirrhosis of the liver; inflammatory diseases of the gallbladder, spleen, pancreas; postcholecystectomy syndrome (after removal of the gallbladder). For the prevention of liver diseases due to the negative effects of toxins of various etiologies: alimentary toxins, drugs, chemotherapy, radiation therapy.
Individual hypersensitivity to the components of the drug.
Impaired renal excretory function.
Antral is administered orally after meals 3 times a day:
The duration of treatment depends on the nature and severity of the disease. The average course of treatment is 3-4 weeks. The course of treatment should be repeated after 3-4 weeks.
In case of overdose, adverse reactions may occur and intensify.
In case of accidental ingestion of large doses of the drug, the stomach should be washed and (if necessary) symptomatic treatment should be carried out.
The drug is generally well tolerated by patients. In rare cases, weakness, dizziness, dyspeptic symptoms, nausea, abdominal pain, diarrhea are possible when using Antralen, which disappear after discontinuation of the drug.
Allergic reactions, including skin rashes, hives, angioedema, redness and itching of the skin.
It is recommended to take Antral 20-30 minutes after a meal, with sufficient water or milk.
Due to limited experience with the drug, it is not recommended to prescribe it during pregnancy or breastfeeding.
The drug should not be used in children under 4 years of age.
There is no data on the effects, but drivers and operators of complex mechanisms should consider the possibility of dizziness.
Antral is compatible with antibacterial, detoxifying, choleretic, and vitamin drugs, which allows it to be included in treatment therapy complexes. When used simultaneously in patients with liver cirrhosis, Antral does not affect the activity of steroid and cytostatic drugs; a reduction (up to 50-70%) of the previously used dose of steroids is allowed without further reduction in the effectiveness of treatment.
Store in the original packaging at a temperature not exceeding 25 °C.
Keep out of reach of children.
Shelf life – 3 years.
Do not use the drug after the expiration date indicated on the package.
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