Belladonna extract rectal suppositories 10 pcs

Active substance: belladonna extract dense;

1 suppository contains: belladonna extract thick ((4.8-5.2): 1) (Belladonnae extractum spissum) extractant 20% (vol / vol) ethanol)) (in terms of the sum of alkaloids 0.00023 g) – 0.015 g (15 mg);

excipients: phenol, solid fat.

Rectal suppositories.

Main physico-chemical properties: suppositories from white with a cream shade to light brown color, bullet-shaped. The presence of plaque on the surface of the suppository is allowed.

Means for the treatment of hemorrhoids and anal fissures for local use.

PBX code C05A Kh.

Pharmacodynamics.

Drug for local treatment of hemorrhoids. The drug has an analgesic, anti-inflammatory and antispasmodic effect.

Belladonna extract has a cholinoblocking effect, weakens intestinal muscle spasm, reduces intestinal peristalsis.

Hemorrhoids, anal fissures.

Hypersensitivity to steppe or to the components of the drug. diseases of the cardiovascular system, in which an increase in heart rate may be undesirable: atrial fibrillation, tachycardia, chronic heart failure, ischemic heart disease, mitral stenosis, severe arterial hypertension. glaucoma. urinary retention or tendency to it. myasthenia gravis diseases of the gastrointestinal tract accompanied by obstruction. hyperthermic syndrome. thyrotoxicosis acute bleeding.

Cardiac arrhythmias occur when used with monoamine oxidase inhibitors; with quinidine, novocainamide – a summation of the cholinolytic effect is observed. can reduce the duration and depth of action of narcotic drugs, weakens the analgesic effect of opiates.

With simultaneous use with Diphenhydramine or Diprazine, the effect of the drug increases; with nitrates, haloperidol, corticosteroids for systemic use – the probability of an increase in intraocular pressure increases; with sertraline – the depressive effect of both drugs increases; with spironolactone, minoxidil – the effect of spironolactone and minoxidil decreases; with penicillins – the effect of both drugs increases; with nizatidine – the effect of nizatidine increases; with ketoconazole – the absorption of ketoconazole decreases; with ascorbic acid and attapulgites – the effect of atropine decreases; with pilocarpine – the effect of pilocarpine in the treatment of glaucoma decreases; with oxprenolone – the antihypertensive effect of the drug decreases. Under the influence of Octadin, it is possible to reduce the hyposecretory effects of atropine, which weakens the effect of M-cholinemimetics and anticholinesterase agents. With simultaneous use with sulfonamide drugs, the risk of kidney damage increases; with drugs containing potassium – the formation of intestinal ulcers is possible; with nonsteroidal anti-inflammatory drugs – the risk of stomach ulcers and bleeding increases.

The effect of the drug may increase with the simultaneous use of other drugs with an antimuscarinic effect: M-cholinoblockers, antiparkinsonian drugs (amantadine), antispasmodics, some antihistamines, drugs of the butyrophenone group, phenothiazines, dispyramides, quinidine and tricyclic antidepressants, non-selective monoamine reuptake inhibitors.

Suppression of peristalsis under the influence of atropine can lead to changes in the absorption of other drugs.

Use with caution in patients with prostatic hypertrophy without obstruction of the urinary tract, with Down’s disease, with cerebral palsy, with liver and kidney failure, with reflux esophagitis; hernias of the esophageal opening of the diaphragm, combined with reflux esophagitis, inflammatory bowel diseases, including nonspecific ulcerative colitis and Crohn’s disease, megacolon; patients with xerostomia, elderly or debilitated patients, with chronic lung diseases without reversible obstruction, with chronic lung diseases accompanied by low production of sputum that is difficult to separate, especially in weakened patients, with autonomic (autonomic) neuropathy, brain damage.

During pregnancy or breastfeeding, the use of the drug is possible only on the doctor’s prescription if the expected benefit for the mother exceeds the potential risk for the fetus / child.

During treatment with the drug, it is recommended to refrain from driving vehicles or performing work that requires increased attention and precise coordination.

Adults should use 1 suppository rectally 2-3 times a day. if necessary, it can be used more often (as prescribed by a doctor).

The duration of the treatment course is determined by the doctor individually, taking into account the course and severity of the disease, the achieved therapeutic effect, and general treatment tactics. The recommended duration of the treatment course is 5-7 days.

There are no data on the safety and efficacy of the drug for children.

Symptoms: increased manifestations of adverse reactions, nausea, vomiting, tachycardia, decreased blood pressure, excitement, irritability, tremors, convulsions, insomnia, drowsiness, hallucinations, hyperthermia, suppression of the central nervous system, suppression of the activity of the respiratory and vascular centers.

Treatment. Parenteral administration of cholinomimetics and anticholinesterase agents. Treatment is symptomatic.

Gastrointestinal disorders: dry mouth, thirst, taste disturbances, dysphagia, decreased intestinal motility up to atony, decreased tone of biliary tract and gallbladder.

From the side of the kidneys and urinary tract: difficulty and delay in urination.

From the side of the heart: a feeling of heartbeat; arrhythmia, including extrasystole; myocardial ischemia.

On the part of blood vessels: redness of the face, hot flashes.

Neurological disorders: headache, dizziness.

On the part of the organs of vision: pupil dilation, photophobia, accommodation paralysis, increased intraocular pressure.

On the part of the respiratory system and mediastinal organs: a decrease in the secretory activity and tone of the bronchi, which leads to the formation of viscous sputum, which is difficult to cough up.

From the side of the skin and subcutaneous tissue: skin rashes, urticaria, exfoliative dermatitis, hyperemia.

From the side of the immune system: anaphylactic reactions, anaphylactic shock.

Others: decreased sweating, dry skin, dysarthria.

3 years.

Store at a temperature not higher than 25 °C.

Keep out of the reach of children.

5 suppositories in a blister, 2 blisters in a pack.

Without a prescription.