Isofra spray nasal solution 8000 IU/ml, 15 ml in a bottle with a sprayer in a cardboard box

Pharmacodynamic parameters. Framycetin is a broad-spectrum aminoglycoside antibiotic for topical use. The action of framycetin disrupts the synthesis of proteins vital for the functioning of the bacterial cell, which leads to the death of the microorganism.

Topical therapy with framycetin creates concentrations that have a bactericidal effect directed at both gram-positive and gram-negative microorganisms – pathogens of upper respiratory tract infections.

Sensitivity to framycetin has been established for corynebacteria, Branhamella catarrhalis, methicillin for staphylococci, acinetobacter (mainly Acinetobacter baumanii), Escherichia coli, campylobacter, representatives of the genus Citrobacter (Citrobacter freundii, Citrobacter koseri), enterobacteria (Enterobacter aerogenes, Enterobacter cloacae), pathogens of listeriosis, hemophilic infection, proteoses (Proteus mirabilis, Proteus vulgaris, Morganella morganii, Providencia rettgeri); Klebsiella, Salmonella, Shigella, Yersinia and Serratia are also sensitive.

Framycetin has moderately pronounced activity against pasteurellosis pathogens.

Enterococci, streptococci, methicillin-resistant staphylococci (mostly hospital strains), Pseudomonas aeruginosa, Nocardia asteroides, flavobacteria, Alcaligenes denitrificans, Providencia stuartii, Burkholderia, Stenotrophomonas maltophilia, chlamydia, mycoplasma, rickettsia, as well as bacteria that do not require oxygen for their vital activity are resistant to framycetin.

1 injection into each nostril (adults – 4-6 times a day, children over 1 year old – 3 times a day). Course – up to 10 days.

When using, keep the bottle in a vertical position; the patient’s head should be slightly tilted forward.

In some cases, allergic reactions are possible: skin itching, urticaria.

Do not use as a means for rinsing the paranasal sinuses.

In a situation caused by prolonged use of the drug, the development of antibiotic-resistant strains of microorganisms is possible.

If there is no effect from therapy within 7 days, the drug should be discontinued.

Not prescribed during pregnancy and breastfeeding.

No effect on the reaction speed when driving or using other mechanisms was noted.

Data is missing.

It is necessary to inform the doctor if the patient is using any other topical medications.

Not found.

At a temperature ≤25 °C in a place inaccessible to children.