Thrombocid gel 15 mg/g tube 40 g

Composition

active ingredient: pentosan polysulfate sodium;

1 g of gel contains 15 mg of pentosan polysulfate sodium salt;

excipients: purified water, isopropyl alcohol, triethanolamine, carbomer, rosemary oil, mountain pine oil, lemon balm oil.

Release form

Gel.

The systemic effect of pentosan polysulfate sodium salt on hemostasis occurs in 3 stages. First, the drug inhibits platelet aggregation induced by collagen or adenosine diphosphate.

Secondly, it affects blood clotting, mainly through antithrombin III-independent inhibition of coagulation factor Xa, interacts with factor VIIIa, and inhibits factor V activation. Unlike heparin, the drug has little effect on thrombin activity.

Third, pentosan polysulfate sodium acts on fibrinolysis: it releases t-PA from the endothelium, activates factor XII, and modifies fibrin production. These effects stimulate thrombin release.

In addition, the drug has a systemic effect on fat metabolism, releasing lipoprotein lipase from endothelial and liver cells, and reduces the level of total cholesterol, total fats and TG in the blood.

The mechanism of action of the heparinoid, pentosan polysulfate sodium salt, is comparable to that of such substances as heparin and heparinoids.

Pentosan polysulfate sodium salt, as a result of local action, enhances capillary blood circulation in the affected tissues due to its fibrinolytic and anticoagulant activity. Thrombocide has an anti-inflammatory effect, inhibits hyaluronidase, reduces increased vascular permeability in the affected tissues and reduces edema. Essential oils have an additional antispasmodic effect and relieve pain in the affected area.

Local symptomatic treatment of superficial phlebitis, thrombophlebitis, varicose veins, which are manifested by edema, pain, a feeling of heaviness in the legs, cramps, trophic ulcers of the lower leg. Sports and household injuries (dislocations, bruises, sprains, hematomas). Tendovaginitis.

Hypersensitivity to pentosan polysulfate sodium salt or any other component of the drug.

Apply a thin layer of the gel to the affected areas and adjacent areas, rubbing in lightly, 3 times a day.

The duration of the treatment course is set individually depending on the patient’s condition, the course of the disease and the achieved effect.

Children: The drug is not intended for use in children under 6 years of age.

Thrombocid gel should not be applied to open wounds. It should be prescribed with caution to the elderly, especially when used concurrently with other medications, including those that affect blood clotting.

There is currently no information or experience on the use of the drug Trombocide during pregnancy and breastfeeding. Pentosan polysulfate sodium salt does not penetrate the placental barrier. Studies conducted on animals have not provided evidence of embryotoxic or fetotoxic effects. However, the drug should not be used during pregnancy.

It is not known whether pentosan polysulfate sodium salt is excreted in breast milk, therefore the drug should not be used during breastfeeding.

The drug does not affect the reaction speed when driving or working with other mechanisms.

Symptoms of intoxication caused by overdose. To date, no case of overdose has been observed.

Therapeutic measures in case of overdose. The antidote for pentosan polysulfate sodium salt is protamine sulfate.

Sometimes hypersensitivity reactions and dry skin may occur at the site of application of the drug.

Like other low molecular weight heparins, pentosan polysulfate sodium salt when administered intravenously, subcutaneously, or intramuscularly may cause heparin-associated thrombocytopenia, which is not dose-related. Although these adverse effects have not been associated with topical use of the drug, if they develop, a doctor should be consulted.

Concomitant use of the drug with heparin or other anticoagulants may lead to increased anticoagulant effects.

At a temperature not exceeding 25 ° C. Shelf life – 5 years.