Valacyclovir Hetero tablets are prescribed for the following indications:
- Treatment of shingles (Herpes zoster).
- Treatment of infections of the skin and mucous membranes caused by the herpes simplex virus, including primary and recurrent genital herpes.
- Treatment of labial herpes (cold sores).
- Preventive treatment (suppression) of recurrences of skin and mucous membrane infections caused by the herpes simplex virus, including genital herpes.
- Reducing transmission of genital herpes virus to a healthy partner when using valacyclovir as suppressive therapy in combination with safe sex.
- Prevention of cytomegalovirus infection and disease after organ transplantation.
Composition
active ingredient: valacyclovir;
1 tablet contains 500 mg of valacyclovir (as valacyclovir hydrochloride);
excipients: microcrystalline cellulose, crospovidone, povidone, magnesium stearate; coating: Opadry White YS-1-7003 (titanium dioxide (E 171), hypromellose, polyethylene glycol 400, polysorbate 80).
Contraindication
Valacyclovir is contraindicated in patients with hypersensitivity to valacyclovir, acyclovir, or any component of the drug.
Method of application
Treatment of herpes zoster: adults should take 1000 mg (2 tablets) of the drug 3 times a day for 7 days.
Application features
Pregnant women
Valacyclovir should only be used in pregnant women if the potential benefit to the mother outweighs the potential risk to the fetus.
Children
It is used in children aged 12 years and older to prevent cytomegalovirus infection and disease.
Drivers
There are no clinical trial data on this issue, and the pharmacology of valacyclovir does not suggest any adverse effects. However, when assessing a patient’s ability to drive or operate machinery, the patient’s clinical condition and the side-effect profile of valacyclovir should be taken into account.
Overdose
Acute renal failure and neurological symptoms, including confusion, hallucinations, agitation, decreased mental status, and coma, have been reported with valaciclovir overdose. Nausea and vomiting may occur. Caution should be exercised when administering valaciclovir to patients with renal impairment or the elderly, in whom the dose was not reduced appropriately.
Adverse reactions
The most common adverse reactions reported in clinical trials were headache and nausea. More serious adverse reactions included reports of thrombotic thrombocytopenic purpura/hemolytic uremic syndrome, acute renal failure, and neurological disorders.
Interaction
Caution should also be exercised (with monitoring of changes in renal function) when co-administering high doses of valacyclovir (4 g or more) and other drugs that affect renal function (e.g. cyclosporine, tacrolimus).
Storage conditions
Store in the original packaging at a temperature not exceeding 25ºС, out of the reach of children.









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