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Bilobil Forte 80 mg ginkgo biloba capsules support memory and attention, improve cerebral circulation, and help reduce dizziness and tinnitus aid
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Bilobil forte capsules 80 mg 6 blisters of 10 pcs.
$43.53
Composition
active ingredient: 1 capsule contains dry extract of ginkgo biloba leaves (Ginkgo biloba L., folium) (ratio of starting materials to extract 35–67:1) containing:
- 17.6–21.6 mg of flavonoids in the form of flavone glycosides;
- 2.24–2.72 mg of ginkgolides A, B, C;
- 2.08–2.56 mg of bilobalide – 80 mg;
- extractant – acetone;
excipients:Â Â lactose monohydrate, corn starch, talc, colloidal anhydrous silicon dioxide, magnesium stearate, glucose solution;
capsule shell:Â Â gelatin, titanium dioxide (E 171), azorubine dye (E 122), red iron oxide (E 172), black iron oxide (E 172).
Dosage form
Capsules.
Main physicochemical properties:Â Â pink capsule. The capsule contains a powder from light to dark brown in color with visible dark particles, the presence of small lumps is possible.
Pharmacotherapeutic group
Means used in dementia. Ginkgo biloba. ATX code N06D X02.
Pharmacological properties
Pharmacodynamics. The herbal preparation normalizes cell metabolism, blood rheological properties, and microcirculation.
Improves cerebral circulation and provides the brain with oxygen and glucose, prevents erythrocyte aggregation, inhibits platelet activation factor. Has a dose-dependent regulatory effect on the vascular system, stimulates the production of endothelium-dependent relaxing factor (nitric oxide – NO), dilates small arteries, increases venous tone, thereby regulating blood filling of vessels. Reduces the permeability of the vascular wall (anti-edema effect both at the level of the brain and on the periphery). Has an antithrombotic effect (due to stabilization of platelet and erythrocyte membranes, influence on the synthesis of prostaglandins, reduction of the action of biologically active substances and platelet-activating factor). Prevents the formation of free radicals and lipid peroxidation of cell membranes. Normalizes the release, reabsorption and catabolism of neurotransmitters (norepinephrine, dopamine, acetylcholine) and their ability to bind to receptors. It has an antihypoxic effect, improves metabolism in organs and tissues, promotes the accumulation of macroergs in cells, increases the utilization of oxygen and glucose, and normalizes mediator processes in the central nervous system.
Pharmacokinetics. Active ingredient – Ginkgo biloba dry extract standardized (EGb761): 24% heterosis and 6% ginkgolides-bilobalides (ginkgolides A, B and bilobalide C).
When taken orally, the bioavailability of ginkgolide A, B and bilobalide C is 80-90%. C max is reached 1-2 hours after taking the drug. T ½ is ≈4 hours (bilobalide, ginkgolide A) and 10 hours (ginkgolide B).
These substances do not break down in the body, are almost completely excreted in the urine, and a small amount is excreted in the feces.
It is not possible to buy Bilobil Forte tablets in Ukraine, since the drug is produced in the form of capsules.
Indication
- Cognitive deficit of various genesis (dyscirculatory encephalopathy due to stroke, traumatic brain injury, in old age, manifested by impaired attention and/or memory, decreased intellectual abilities, feelings of fear, sleep disorders) and neurosensory deficit of various genesis (senile macular degeneration, diabetic retinopathy); lameness in chronic obliterating arteriopathy of the lower extremities (Fontaine stage II); visual impairment of vascular genesis, decreased acuity; hearing impairment, tinnitus, dizziness and coordination disorders, mainly of vascular genesis; Raynaud’s syndrome.
Application
1 capsule 2-3 times a day during meals. Wash down with ½ glass of water. Average duration of treatment course – 3 months.
Cognitive disorders: prescribe 1 capsule of 80 mg 2-3 times a day. The duration of treatment is at least 8 weeks. After 3 months of therapy, the doctor should make sure of the need for further use of the drug.
Peripheral arterial occlusive disease, as well as dizziness of vascular and involutional origin: prescribe 1 capsule of 80 mg 2 times a day. The duration of treatment is at least 8 weeks.
For dizziness, the duration of therapy is no more than 6-8 weeks.
The duration of treatment for tinnitus is at least 12 weeks.
Contraindication
Hypersensitivity to ginkgo biloba extract or to any other component of the drug.
Side effects
Gastrointestinal tract: dyspeptic phenomena, nausea, vomiting, gastrointestinal disorders.
On the part of the immune system: hypersensitivity reactions or allergic reactions.
From the nervous system: headache, dizziness.
Skin: hypersensitivity reactions, including itching, redness, rash, swelling.
In rare cases, when using drugs containing ginkgo biloba extract, especially when used simultaneously with anticoagulants (such as phenprocoumon and acetylsalicylic acid), hemorrhages (gastrointestinal, eye, brain) occur.
The drug contains the dye azorubine (E122), which in some cases may cause allergic reactions and bronchospasm.
If any adverse reactions occur, you should stop using the drug and be sure to consult a doctor.
Special instructions
The first signs of improvement appear 1 month after the start of treatment.
In case of a pathologically increased tendency to bleed (hemorrhagic diathesis), as well as in the case of simultaneous use of anticoagulants, the drug should be taken only after consulting a doctor.
If an allergic reaction occurs, the patient should stop taking the drug.
Since there is evidence that preparations containing ginkgo biloba extract increase the tendency to bleed, taking this preparation should be discontinued before surgical operations.
The medicine contains lactose and glucose. Patients with rare hereditary forms of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine.
Use during pregnancy and breastfeeding. Due to the lack of clinical data, the drug is not recommended for use during pregnancy and breastfeeding.
Children. There is no sufficient experience with the use of the drug in children, therefore treatment of this category of patients is not recommended.
Ability to influence the reaction rate when driving vehicles or working with other mechanisms. During treatment, caution should be exercised when driving vehicles or engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.
Interactions
The drug should not be taken if the patient is taking acetylsalicylic acid, warfarin, or thiazide diuretics for a long time.
When used simultaneously with drugs that inhibit blood coagulation (such as phenprocoumon and acetylsalicylic acid), the effect of the latter may be enhanced – the risk of bleeding increases.
The simultaneous use of ginkgo biloba extract with the following drugs requires special supervision:
- Ginkgo biloba increases the metabolism of antiepileptic drugs that are metabolized through the CYP 2C enzyme system. With concomitant therapy, antiepileptic drugs (valproate, phenytoin) can lower the seizure threshold, which increases the possibility of an epileptic seizure;
- The interaction of Ginkgo biloba extract with drugs that are metabolized by the cytochrome P450 enzyme system cannot be completely ruled out (in some cases, there is a possibility of displacement or induction of some isoenzymes).
Overdose
In case of overdose or R, dyspeptic disorders, impaired consciousness and headache may occur. Treatment is symptomatic.
Storage conditions
In a place protected from moisture at a temperature not exceeding 25 °C.
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