Panangin film-coated tablets 60 pieces

• Additional therapy for chronic heart diseases (heart failure, post-infarction period), heart rhythm disorders, primarily ventricular arrhythmias, on the recommendation of a doctor.
• Additional therapy when treating digitalis with drugs, as recommended by a doctor.
• As a dietary supplement to increase magnesium and potassium levels in the body.

• active ingredients: magnesium asparaginate, potassium asparaginate;
• 1 film-coated tablet contains 140 mg of magnesium asparaginate (as 175 mg of magnesium asparaginate tetrahydrate) equivalent to 11.8 mg of Mg2+;
• 158 mg of potassium asparaginate (as 166.3 mg of potassium asparaginate hemihydrate) is equivalent to 36.2 mg of K+;
• Excipients: colloidal anhydrous silicon dioxide; potato starch; povidone; magnesium stearate; talc; corn starch; macrogol 6000; titanium dioxide, E 171; methacrylate-based copolymer (Eudragit E 100).

• Hypersensitivity to the active substances or to any of the excipients of the drug.
• Acute and chronic renal failure, Addison’s disease, third-degree atrioventricular block, cardiogenic shock (blood pressure < 90 mm Hg).

On the part of the gastrointestinal tract: when using large doses of the drug, an increase in the frequency of bowel movements may be observed.

According to some reports, nausea, vomiting, and abdominal pain may occur.

The usual daily dose for adults is 1-2 tablets 3 times a day. The dose can be increased to 3 tablets 3 times a day. Gastric juice can reduce the effectiveness of the drug, so it is recommended to take the tablets after meals.

The course of treatment is determined by the doctor.

Use during pregnancy or breastfeeding

To date, no harmful effects have been reported when using the drug in this category of patients.

Children

The use of the drug in children is not recommended due to insufficient experience in use.

The ability to influence the reaction speed when driving or working with other mechanisms

The drug does not affect the ability to drive vehicles and other mechanisms.

Cases of overdose are unknown.

Given the ability of the kidneys to excrete large amounts of potassium from the body, increasing the dose of the drug may lead to hyperkalemia only if it is associated with acute or severe impairment of potassium excretion.

The therapeutic index of magnesium is wide, and in the absence of renal failure, severe side effects are extremely rare.

According to scientific data, taking magnesium supplements orally may cause minor side effects, such as diarrhea.

Large doses of Panangin, film-coated tablets, may cause an increase in bowel movements due to the magnesium content.

In case of rapid intravenous administration, symptoms of hyperkalemia/hypermagnesemia may occur.

Symptoms of hyperkalemia: general weakness, paresthesias, bradycardia, paralysis. Extremely high plasma potassium concentrations can lead to death from cardiac depression, arrhythmia, or cardiac arrest.

Symptoms of hypermagnesemia: nausea, vomiting, drowsiness, hypotension, bradycardia, weakness, slurred speech, double vision. At very high plasma concentrations of magnesium, hyporeflexia, muscle paralysis, respiratory arrest and cardiac arrest may develop.

In case of overdose, it is necessary to cancel K+-, Mg2+-aspartate and it is recommended to carry out symptomatic treatment (calcium chloride 100 mg/min intravenously, dialysis, if necessary).

Tetracyclines used internally, iron salts and sodium fluoride inhibit the absorption of the drug from the gastrointestinal tract. In combination therapy with the above drugs, a break of at least 3 hours is required between doses. Simultaneous use of the drug with potassium-sparing diuretics and/or angiotensin-converting enzyme inhibitors, beta-blockers, cyclosporine, heparin, nonsteroidal anti-inflammatory drugs increases the risk of developing hyperkalemia.

Store at a temperature not exceeding 25 ºС.

Keep the drug out of the reach of children.