Beres Magnesium plus B6 film-coated tablets 30 pieces

Combined drug, contains magnesium and vitamin B6.

Magnesium is a mineral that affects almost all body functions. Its most important actions are as follows: participation in energy processes. ATP, which is a chemical source of energy, can enter the process of energy formation only in the form of magnesium salt. Magnesium is also a cofactor of the enzyme that catalyzes this process, it is a structural element for the formation of bones and teeth; regulates the permeability of cell membranes and cell organelles (including mitochondrial), which leads to increased elasticity of blood vessel walls, improved contractility of the heart muscle, and reduced risk of arrhythmia; participates in the activity of more than 300 enzymes; protects cells from excessive calcium intake; is a calcium antagonist, and in this capacity plays a regulatory role in a number of biological processes; indirectly increases the activity of the antioxidant defense system; reduces the risk of developing convulsive states (eclampsia, preeclampsia), primarily during pregnancy; has antithrombotic activity.

Vitamin B6 ₍ pyridoxine) – as a coenzyme participates in protein metabolism (reamination, decarboxylation, deamination, peresulfuration, formation of nicotinic acid from tryptophan, hemoglobin synthesis); as a coenzyme participates in carbohydrate and fatty acid metabolism (conversion of glycogen into glucose-1-phosphate, conversion of linoleic acid into arachidonic acid, etc.).

Magnesium is actively absorbed in the upper small intestine. The degree of absorption is 30-40% of the dose taken. Magnesium citrate and magnesium oxide have a good absorption profile. Special transport through cytoplasmic and mitochondrial membranes is characteristic. In the regulation of internal levels of Mg ²⁺ (cytoplasmic and mitochondrial), the main element is the enzyme Ca ⁺⁺ -Mg ^{++ -adenosine triphosphatase. Normally, the movement of calcium and magnesium is opposite. On average, the Mg 2+} content in the adult body is 1000 mmol. About 50% of this amount is included in bone tissue (30% of this amount can vary). Intracellular and extracellular magnesium are 45 and 5%, respectively. In blood plasma, the concentration of magnesium varies from 0.75 to 1.20 mmol / l, with 30% of magnesium in blood plasma bound to proteins. It interacts to a large extent with calcium, to a lesser extent with potassium.

Most of the magnesium is incorporated into bones and teeth, which is not replaceable, but magnesium is also deposited in muscle tissue, kidneys, liver, and heart.

The main route of magnesium excretion from the body is through the kidneys (range 1-250 mmol), but they also participate in the conservation of magnesium in the body by reabsorption of the main amount in the proximal tubules (in the ascending segment of the loop of Henle), with excretion accounting for approximately 3-5% of filtered magnesium.

Various forms of vitamin B ₆ are absorbed by passive diffusion, mainly in the small intestine and ileum. In the blood, the main form of vitamin _{B 6} is pyridoxal phosphate, bound to blood plasma proteins (albumin), only a small part of it is in the form of free pyridoxal. Pyridoxal is more able to penetrate cell membranes than its phosphate form. Pyridoxal, having passed through the cell membrane, is again phosphorylated with the participation of kinase, and thus, the main tissue form is pyridoxal phosphate. The vitamin is deposited in two forms: partly in the form of pyridoxal phosphate, partly – pyridoxamine phosphate. In the protein-bound state, a more significant amount can be found in the liver, kidneys, brain, spleen and skeletal muscles.

It is excreted in the urine in the form of various metabolites, the main of which is 4-pyridoxine acid.

The metabolism of all components is significantly reduced with insufficient kidney function.

Treatment of magnesium deficiency. Prevention of magnesium deficiency in conditions accompanied by an increased need for it (pregnancy, breastfeeding, increased physical activity).

Replenishment of the proper level of magnesium in the body in primary deficiency caused by reduced magnesium intake with food (restrictive diets), as well as in secondary magnesium deficiency caused by either reduced absorption (pancreatic insufficiency, Crohn’s disease, nonspecific ulcerative colitis), or increased magnesium losses (diarrhea, increased urinary excretion, burns), as well as in secondary magnesium deficiency caused by certain types of drug therapy (some antibiotics, immunosuppressants, diuretics and chemotherapeutic drugs). For prophylactic purposes in chronic physical and mental fatigue, irritability, stress, depression, sleep disorders, headache, myalgia, intense physical and mental exertion.

Additional therapy for the prevention of magnesium deficiency in: the aging process, diseases with impaired carbohydrate metabolism characterized by insulin resistance (obesity, reduced glucose tolerance, non-insulin-dependent diabetes mellitus), hypertension, coronary heart disease, certain types of cardiac arrhythmias, stroke.

The usual dose for adults is 1 tablet per day.

Children aged 2-10 years are prescribed ½ tablet once a day (if necessary, the tablet can be crushed). Children over 10 years are prescribed 1 tablet once a day.

During pregnancy and breastfeeding, the drug can be taken in the usual daily dose for adults.

The tablets should be taken after meals and washed down with sufficient water. The duration of treatment is determined individually.

Hypersensitivity to the components of the drug, simultaneous use of other drugs containing magnesium, hypermagnesemia, severe renal failure, children under 2 years of age.

When using the drug very rarely (in cases where the recommended dose is exceeded), diarrhea or abdominal pain may occur. In such cases, the use of the drug should be discontinued.

The drug does not affect the ability to drive vehicles and work with potentially dangerous mechanisms.

Magnesium reduces the absorption of some oral medications (tetracycline, calcium preparations, iron compounds, bisphosphonates), therefore the interval between taking these drugs and the drug Beres Magnesium Plus B6 should be at least 3 hours.

Potassium-sparing diuretics can increase tubular reabsorption of magnesium, so they can be taken only under the supervision of a doctor. Magnesium can reduce the level of digitalis glycosides in the blood plasma, so patients taking digitalis preparations should be prescribed Beres Magnesium plus B6 _only under constant supervision of a doctor.

Vitamin B6 _can only be taken simultaneously with drugs containing levodopa (their effectiveness may decrease) under the supervision of a doctor.

Symptoms of overdose can occur only with prolonged use of the drug in doses that many times exceed the recommended daily dose. Symptoms of possible intoxication: weakness, nausea, vomiting, bradycardia, hyporeflexia, paresthesia and in severe cases – delirium. As an antidote, calcium compounds can be used, 100-200 mg i.v. for 5-10 min. In addition, hemodialysis can be performed.

In a dry place at a temperature of 15-25 °C.