Jox Teva oral spray with atomizer bottle 30 ml

Pharmacodynamics. Povidone-iodine, a disinfectant substance belonging to the group of substances containing iodine, releases organic iodine upon contact with the skin or mucous membrane, has a wide spectrum of antimicrobial action due to its direct effect on the proteins of microorganisms. Povidone-iodine has a partially bactericidal effect on gram-positive and gram-negative cocci and bacilli, on some anaerobic bacteria, yeasts or saccharomyces, simple viruses.

The drug also contains allantoin, which has an anti-inflammatory effect, due to which, together with povidone iodine, the therapeutic effect of the drug is achieved.

Pharmacokinetics. When povidone iodide is applied topically to intact skin, iodine absorption is minimal. When applied orally, more pronounced systemic absorption of iodine is noted, which may result in interference with thyroid function. Iodine in the body is converted to iodides, which accumulate mainly in the thyroid gland and are excreted mainly by the kidneys, as well as in small quantities with feces, saliva, and sweat. Iodides pass through the placental barrier and penetrate into breast milk.

Disinfection of the oral cavity and throat in inflammatory and infectious diseases: tonsillitis, pharyngitis, tonsillopharyngitis, tonsillitis, glossitis and stomatitis; as part of complex treatment with antibiotics for streptococcal tonsillitis; the first symptoms of acute respiratory viral infections.

Jox mouthwash is applied topically to the mucous membrane of the oral cavity and pharynx.

Adults and children over 6 years of age. The diluted solution is used to rinse or wash the mouth and throat. Do not swallow the solution. Rinse or wash the mouth and throat with 10-15 ml of the diluted solution for about 30 seconds. Apply 2-4 times a day, no more than 6 times a day, with an interval between two applications of at least 4 hours.

For dilution, use drinking water at a temperature of 18 °C in a ratio of 1: 20-1: 40 (namely: 2.5-5 ml when using a measuring cap or ½-1 teaspoon per 100 ml of water). Lightening of the solution means a decrease in its antimicrobial activity.

Elderly patients and those with liver failure are shown the same doses as adults.

Jox spray. The spray is applied topically to the mucous membrane of the oral cavity and pharynx.

The drug is sprayed in a dosed manner from a bottle with a mechanical sprayer and an applicator for the oral cavity.

If the oral applicator is in a plastic bag, it must be cut with scissors or another convenient tool and the applicator removed.

Before use, the oral applicator should be rinsed with warm water and checked for damage. A damaged applicator should not be used.

Remove the protective cap from the mechanical sprayer. Place the applicator on the bottle.

Press 2-3 times until the solution enters the sprayer and starts spraying after pressing.

Insert the applicator tube into the oral cavity, hold your breath and press 2 times, each time directing the jet of the drug to the corresponding area of ​​the throat cavity on the right and left. When using the bottle, it is necessary to hold it vertically.

Do not inhale or swallow the sprayed solution!

It is used in adults and children over 8 years of age, as a rule, 2-4 times a day, if necessary – every 4 hours.

The spray can be applied no more than 6 times a day.

Elderly people and patients with hepatic insufficiency should have their dose adjusted (see Precautions).

The duration of treatment depends on the nature and course of the disease and is determined by the doctor individually.

Hypersensitivity to the components of the drug; dermatitis herpetiformis of Duhring; hyperthyroidism, adenoma or dysfunction of the thyroid gland; decompensated heart failure; renal failure; 2 weeks before and after examination or therapy with radioactive iodine.

The drug is usually well tolerated.

The frequency of adverse events was estimated according to the following principle: very common (≥1/10), common (≥1/100, 1/10), uncommon (≥1/1000, 1/100), rare (≥1/10,000, 1/1000), very rare (1/10,000), including isolated reports.

On the part of the immune system: very rarely – anaphylactic shock.

On the part of the digestive system: infrequently – dry mouth.

Skin and subcutaneous tissue disorders: rarely – hypersensitivity reactions, including urticaria; very rarely – angioedema. Itching, hyperemia are also possible.

General disorders and administration site conditions: infrequently – burning sensation at the application site (especially in children), dry mouth.

Damage, poisoning and complications during the procedure: iodism (metallic taste in the mouth, increased salivation, swelling of the eyes, larynx, lungs, skin rash, gastrointestinal disorders, systemic manifestations in the form of metabolic acidosis, hypernatremia, impaired renal function, diarrhea) after prolonged use.

The drug is not intended for oral administration: the drug should not be swallowed. If the patient’s condition does not improve within 3 days or there are undesirable effects or unusual sensations, it is necessary to consult a doctor.

It is not advisable to use the drug simultaneously with other antiseptic drugs intended for use in the oral cavity and throat.

For laryngitis, the drug can be used only in exceptional cases.

The drug contains 18.6% ethanol.

The drug should be used with caution in patients with hepatic insufficiency. In such patients, transaminase levels may increase, so it is necessary to monitor their levels in the blood plasma.

The use of povidone-iodine may interfere with thyroid scintigraphy. Povidone-iodine should not be used for 1-2 weeks prior to thyroid scintigraphy.

Since the development of hyperthyroidism cannot be ruled out, prolonged (more than 14 days) use of povidone-iodine or its use in large quantities in patients (especially the elderly) with latent thyroid dysfunction is permissible only after careful consideration of the expected benefit and possible risk. Such patients should be monitored for early signs of hyperthyroidism and appropriate examination of thyroid function, even after discontinuation of the drug (for a period of up to 3 months).

Do not inhale or swallow the spray solution. Avoid contact with eyes. If the product gets into eyes, rinse with water.

The drug may stain the mucous membrane of the oral cavity, teeth, skin and clothing. Stains on the mucous membrane, teeth and skin can be removed with alcohol. Stains on clothing can be removed by washing and rinsing with diluted ammonia (rubbing alcohol), sodium thiosulfate or soap and water.

If possible, dentures and similar structures should be removed from the mouth before applying the drug.

The drug should not be heated before use, as the decomposition of active substances is enhanced in light and at temperatures above 40 °C.

Use during pregnancy and breastfeeding. There is no experience with the topical use of povidone-iodine in pregnant women. Congenital hypothyroidism or goiter has been observed in newborns whose mothers used topical iodine (after vaginal application before delivery or application to the skin during pregnancy). Therefore, povidone-iodine should not be used during pregnancy.

Iodine can pass into breast milk. The detected iodine concentrations in the blood and urine of breast-fed infants were many times higher than those observed in their mothers who used povidone-iodine. High plasma iodine concentrations can lead to the development of congenital hypothyroidism in breast-fed infants, therefore povidone-iodine should not be used during breast-feeding.

Children. Yox rinse is used in children over 6 years of age; Yox spray – in children over 8 years of age. Children aged 8 to 12 years should use the drug under the supervision of a physician. Children should use the drug with caution, given the possibility of laryngospasm.

Ability to influence the reaction rate when driving vehicles or working with other mechanisms. The use of the drug does not affect the ability to drive vehicles or work with other mechanisms.

It is not recommended to combine the drug with other antiseptic agents for the mouth and throat, primarily with hydrogen peroxide.

Due to its oxidizing properties, povidone-iodine may interfere with the results of some diagnostic tests, such as the detection of occult blood in feces or urine, or glucose in urine. The use of the drug leads to false-positive results of Hemotest. May interfere with the results of some diagnostic tests (e.g. thyroid scintigraphy, determination of protein-bound iodine, measurement of radioactive iodine) or may compete with iodine used for thyroid therapy.

The use of povidone iodine should be avoided in patients taking lithium preparations, as their simultaneous use may cause a synergistic hypothyroid effect.

Povidone-iodine should not be used simultaneously with drugs containing chlorhexidine, silver sulfadiazine due to possible partial inactivation. Povidone-iodine interacts with strong alkalis, sodium thiosulfate, sodium metabisulfite and thiomersal, so the drug should not be used simultaneously with these substances.

All interactions are visually manifested by discoloration of the solution, which indicates a decrease in the effectiveness of the drug.

The drug should not be used simultaneously with disinfectants containing mercury; ointments containing enzymes, or benzoin tincture; the drug is incompatible with oxidants, alkali salts, and substances with an acidic reaction.

With proper local application of the drug in the oral cavity or pharynx, no cases of overdose were observed. However, in the case of swallowing iodine solution, acute poisoning developed. Patients initially felt a metallic taste in the oral cavity, vomiting, stomach pain and diarrhea began. Anuria, swelling of the glottis with subsequent asphyxia, aspiration pneumonia or pulmonary edema were observed within 1-3 days. In some cases, vascular collapse was noted.

Treatment is symptomatic and initially includes standard measures to prevent further absorption in the gastrointestinal tract. The patient should drink milk and brewed starch. (To brew starch, take 2 g of starch in a porcelain cup and mix well with 8 ml of cool clean water. Add 90 ml of boiling purified water. Stirring constantly, heat the mixture to a boil (0.5-1 min) and hold until it thickens and becomes lighter. Cool to room temperature (25 °C) and take). If the esophagus is not damaged, gastric lavage can be performed. In addition, it is necessary to take activated charcoal and 1-5% sodium thiosulfate solution, which ensures the reduction of iodine to iodide. There is no specific antidote.

Rinse aid – in original packaging at a temperature not exceeding 25 °C in a place protected from light; spray – in original packaging to protect from moisture.

ABMR-UA-00003