Cholisal oral gel tube 10 g

The effects of the drug are due to the synergistic effect of its components: anti-inflammatory, analgesic and antiseptic. the main active substance of the drug – choline salicylate – has a local anti-inflammatory and weak analgesic effect. the mechanism of analgesic, antipyretic, and anti-inflammatory action of salicylates is associated with inhibition of COX activity, as well as thromboxane synthetase activity. as a result, the synthesis of prostaglandins is inhibited, primarily prostaglandins e and f in tissues affected by inflammation, in the wall of the gastrointestinal tract and kidneys. used locally, in normal doses it does not have a systemic effect. Cetalkonium chloride enhances the analgesic and anti-inflammatory effect. antiseptics included in the base gel, methyl parahydroxybenzoate and propyl parahydroxybenzoate (in concentrations of 0.15 and 0.08%, respectively) have an antibacterial effect.

Choline salicylate quickly penetrates mucous membranes (approximately 2 times faster than acetylsalicylic acid). Salicylates easily penetrate most tissues and body fluids. They have a high affinity for blood proteins and tissues, binding (50-80%) to blood plasma albumins. T _½ of salicylates – 2-4 h. Biotransformation of salicylates occurs in tissues, mainly in the liver to salicylic acid, from which salicyluric acid, glucuronides, acetal, and gentisic acid are formed. Biotransformation products are excreted in the urine (75% is salicyluric acid). About 10% of salicylates are excreted unchanged in the urine. Excretion is slow, about 50% of the dose is excreted in 24 hours.

Inflammatory processes of the mucous membrane of the oral cavity; erosions and ulcers of the mucous membrane of the oral cavity; gingivitis; periodontitis

 

Apply a small amount of gel to the affected area and gently rub for 2 minutes. used 2-3 times a day. a column of gel 1 cm long for adults and 0.5 cm for children is gently rubbed for several minutes into the affected area of ​​the mucous membrane.

In the treatment of periodontal diseases, the gel should be placed in the gum pockets 1-2 times a day, as well as applied in the form of compresses or gently rubbed into the gums 1-2 times a day. The duration of treatment is determined depending on the clinical situation. Do not rinse your mouth with water or eat for 30 minutes after using the gel.

Hypersensitivity to choline salicylate, to other salicylates, cetalkonium chloride or to any of the components of the drug.

A short-term burning sensation may appear at the site of application, which passes over time. due to the presence of methylparaben and propylparaben in the composition, the development of allergic reactions is possible.

A short-term burning sensation may occur at the application site, which will eventually pass.

The drug contains methylparaben and propylparaben, which can cause irritation. If any unwanted reactions occur, you should stop using the drug and consult a doctor.

Use during pregnancy and breastfeeding. No studies have been conducted on the duration and degree of absorption of choline salicylate after local application of the gel on the mucous membranes of the oral cavity. During pregnancy should be used with caution, taking into account the risk / benefit. Derivatives of salicylic acid are contraindicated in the III trimester of pregnancy. Substances penetrate into breast milk, so it is not recommended to use them during breastfeeding.

The ability to influence the speed of reaction when driving vehicles or working with complex mechanisms. The drug does not impair psychophysical performance and does not affect the ability to drive vehicles and work with complex mechanisms.

Children. Do not use in children under 3 years of age.

With local application of Cholisal in accordance with the recommended dose, there is no risk of any interaction. only in case of a significant overdose and the development of symptoms of systemic action of choline salicylate, it should be taken into account that it synergistically interacts with other anti-inflammatory, antipyretic and pain-relieving drugs.

Theoretically impossible. however, if this happens, rinse the mouth with plenty of water and, if necessary, induce vomiting.

With increased sensitivity to salicylates, after an overdose of the gel and absorption of a significant amount of choline salicylate into the body, symptoms of the systemic effect of salicylates may appear: increased sweating, tinnitus, nausea, vomiting, dizziness, skin rashes (erythema or urticaria). Treatment is symptomatic.

At a temperature not higher than 25 °C, do not freeze.