Ketodin cream 20 mg/g tube of 15 g

Ketoconazole is a synthetic derivative of imidazoledioxolane. It has fungicidal and fungistatic effects on dermatophytes (trichophyton spp., epidermophyton floccosum, microsporum spp.), yeast fungi (candida spp., pityrosporum spp., torulopsis, cryptococcus spp., rhodotorula spp.), dimorphic and higher fungi (eumycetes). Aspergillus spp., Sporothrix schenckii, some dermatiaceae, mucor spp. and other fucomycetes are less sensitive to ketoconazole, with the exception of entomophthrales. Ketoconazole is also active against cocci (staphylococcus spp., streptococcus spp.). The mechanism of action is to inhibit ergosterol biosynthesis, which leads to a change in the lipid composition of the fungal membrane and their lysis. The development of secondary resistance during treatment with ketoconazole has not yet been observed. The drug quickly eliminates peeling and itching of the skin.

When applied topically, the drug does not have a systemic effect; absorption of Ketodin cream through the skin is extremely slight or non-existent.

Treatment of skin infections caused by dermatophytes or yeast-like fungi sensitive to the drug (candidiasis of skin folds, inguinal epidermophytosis, epidermophytosis of the feet).

Ketodine cream should be applied to the affected area, as well as to the areas immediately adjacent to it.

For the treatment of athlete’s foot, Ketodin cream is recommended to be applied to the affected skin and adjacent areas 2 times a day. The course of treatment should be continued for 1 week. In case of more severe skin lesions, treatment should be continued for another 2-3 days after the disappearance of all symptoms to avoid relapse of the disease.

For the treatment of inguinal epidermophytosis and candidiasis of skin folds, Ketodin cream is recommended to be applied to the affected skin and adjacent areas 2 times a day. Treatment should continue for a sufficient period of time, at least 2-3 days after the disappearance of all symptoms, to avoid relapse of the disease.

If necessary, treatment may last up to 6 weeks.

If the symptoms of the disease do not disappear after using the drug for 1 month, you should consult a doctor.

Hypersensitivity to ketoconazole and/or other components of the drug.

When using ketoconazole, the following were noted:

general disorders and reactions at the site of application – discomfort, dryness, erythema, itching, inflammation, irritation, bleeding, paresthesia;

Skin and subcutaneous tissue disorders – burning, hives, bullous rashes, contact dermatitis, peeling or stickiness of the skin;

If the drug is used immediately after prolonged treatment with local corticosteroids, skin irritation may occur, to eliminate which it is recommended to continue local treatment with corticosteroids in the morning, and use Ketodin cream in the evening. Gradually, over 2-3 weeks, the dose of corticosteroids is reduced until it is completely discontinued.

Ketodine cream should not be used in ophthalmological practice.

Propylene glycol may cause skin itching. Cetyl alcohol and stearyl alcohol may cause local skin reactions (e.g. contact dermatitis).

Use during pregnancy and lactation. There are no adequate and well-controlled studies of the use of ketoconazole in pregnant and breastfeeding women. The risks associated with the use of the drug during pregnancy and lactation are unknown.

Children. There is no experience with the use of Ketodine cream in children.

The ability to influence the reaction speed when driving vehicles or working with other mechanisms. Does not affect.

Not detected.

Topical application. In case of accidental application of a large amount of cream to the skin, erythema, edema, and burning sensation of the skin may occur, which quickly disappear after discontinuation of therapy.

Accidental ingestion: In case of accidental ingestion, supportive and symptomatic therapeutic measures should be administered.

At a temperature of 25 °C.