Mezym forte 20000 enteric-coated tablets 20 pieces

• active ingredient: powder from pancreas (pigs);
• 1 enteric-coated tablet contains 160–222.22 mg of porcine pancreatic powder, which has a minimum lipolytic activity of 20,000 EF units (European Pharmacopoeia units), a minimum amylolytic activity of 12,000 EF units, and a minimum proteolytic activity of 900 EF units;
• Excipients: lactose monohydrate, microcrystalline cellulose, colloidal anhydrous silica, crospovidone, magnesium stearate, hypromellose, methacrylate copolymer (type A), triethyl citrate, titanium dioxide (E 171), talc, simethicone, polyethylene glycol, polysorbate, carmellose sodium, vanilla flavor, bergamot flavor, sodium hydroxide.

Hypersensitivity to the active substance, pig meat (pork allergy) or to any of the excipients of the medicinal product.

Acute pancreatitis or chronic pancreatitis in the exacerbation phase (but episodic use is possible in the phase of subsiding exacerbation when expanding the diet in the presence of pancreatic function disorders). The drug should not be used in patients with obstructive intestinal obstruction.

Immune system disorders: Very rare: immediate allergic reactions (skin rash, urticaria, sneezing, lacrimation, bronchospasm, dyspnoea), hypersensitivity reactions localized in the gastrointestinal tract.

Gastrointestinal: Very rare: diarrhea, abdominal discomfort, abdominal pain, nausea, vomiting. Formation of strictures in the ileocecal region and in the ascending colon has been described after administration of pancreatic powder in high doses.

Recommended dose per meal: 1–2 tablets (corresponds to 20,000–40,000 IU of EF lipase).

The dose of Mezym forte  20000 is determined according to the severity of the existing pancreatic insufficiency. Usually the recommended dose is 20000–40000 IU of lipase per meal, but it may be higher.

The goal of treatment with Mezym Forte  20000 is to achieve or maintain normal body weight and normalize the frequency of defecation or stool consistency. Increasing the dose should only be done under the supervision of a physician and to relieve symptoms (e.g. steatorrhea, stomach pain).

The daily dose of enzymes should not be exceeded, which is 15,000–20,000 U of lipase per kilogram of body weight.

Mezym Forte 20000 tablets  should be swallowed whole, washed down with plenty of liquid, during meals, since the effectiveness of the drug Mezym  forte 20000 may decrease when chewed, and the enzymes contained in the drug, when released in the oral cavity, may damage its mucous membrane.

The duration of treatment depends on the course of the disease and is determined by the doctor.

Use during pregnancy or breastfeeding

There are no adequate data on the use of Mezym forte 20000 in pregnant women. There is insufficient data on the effects on pregnancy, embryonal/fetal development, parturition or postnatal development obtained in animal experiments, so the potential risk to humans is unknown. In this regard, Mezym forte 20000 should not be taken during pregnancy and lactation, except in cases where its use is absolutely necessary.

Children

The drug Mezym  forte 20000 is used to treat children aged 3 years and older. The dosage and duration of treatment are determined by the doctor.

Ability to influence reaction speed when driving vehicles or other mechanisms

The effect of Mezym forte 20000 on the ability to drive vehicles or operate other mechanisms is absent or insignificant.

The use of very high doses of pancreatic enzymes may be accompanied by hyperuricosuria and hyperuricemia. Treatment is symptomatic.

Folic acid.

When using ready-made medicines containing pancreatin, the absorption of folic acid may decrease, which may result in the need for its additional intake into the body.

Acarbose, miglitol.

The blood sugar-lowering effect of oral antidiabetic drugs acarbose and miglitol may be reduced when used simultaneously with the drug Mezym Forte  20000.

Store at a temperature not exceeding 30 ° C. Keep out of the reach of children.