Natubiotin tablets 10 mg blister 30 pcs.

• active ingredient: biotin;
• 1 tablet contains 10 mg of biotin;
• Excipients: microcrystalline cellulose; lactose monohydrate; povidone K30; crospovidone; magnesium stearate.

Hypersensitivity to biotin or to other components of the drug.

Special safety measures.

Raw egg white contains the protein avidin, which interacts with biotin, so you should avoid taking them together.

Eating a large amount of raw eggs for 2-3 weeks can cause biotin deficiency.

The drug contains lactose, therefore patients with rare hereditary forms of galactose intolerance, lactase deficiency or glucose-galactose malabsorption syndrome should not use the drug.

The recommended dose for adults in the treatment of biotin deficiency (diseases of nails, hair, skin) is 1 tablet of 5 mg per day.

For the treatment of genetically determined enzymopathies associated with biotin (multiple carboxylase deficiency), 1-2 tablets are prescribed (daily dose – up to 20 mg of biotin). The tablets should be taken before meals, without chewing, with sufficient liquid.

The duration of the treatment course depends on the nature and course of the disease.

Impact on clinical laboratory tests.

Depending on the test, results may be falsely high or falsely low due to taking a biotin-containing medicine. The risk of exposure is higher in children and patients with impaired renal function and increases with higher doses.

When interpreting laboratory test results, the possible influence of biotin should be considered, especially if there is a lack of agreement with the clinical picture (e.g., thyroid test results mimicking Graves’ disease in asymptomatic patients taking biotin, or false-negative troponin test results in patients with myocardial infarction taking biotin). When interference is suspected, alternative tests that are immune to biotin interference should be used.

When ordering laboratory tests, patients taking biotin should consult with laboratory personnel.

Use during pregnancy or breastfeeding

According to generally accepted principles, Natubiotin should be used during pregnancy or breastfeeding only if the expected benefit to the woman outweighs the potential risk to the fetus/child.

There is no information yet on the negative effects of the drug during pregnancy or breastfeeding. Biotin crosses the placenta and enters breast milk. Breast milk usually contains 7-13 mcg of biotin/l.

Children

Due to limited experience, the drug is not used in children under 12 years of age.

Children over 12 years of age should use the drug as prescribed by a doctor; there are no dosage recommendations due to limited data.

Ability to influence reaction speed when driving vehicles or other mechanisms

Does not affect.

To date, there have been no reports of biotin overdose.

On the part of the immune system: very rarely (< 1/10,000) allergic reactions, including urticaria.

If any adverse reactions occur, it is recommended to discontinue treatment and consult a doctor.

When using biotin with anticonvulsants, a decrease in the concentration of biotin in the blood plasma is possible due to increased urinary excretion. Valproic acid reduces the activity of biotinidase, reducing the function of mitochondria in the liver.

Pantothenic acid in large doses competes with biotin, so their simultaneous use should be avoided.

Store in the original packaging at a temperature not exceeding 25 °C, out of the reach of children.