Papazol Darnitsa tablets blister 10 pcs

Papazol Darnitsa is a combined drug that contains the alkaloid papaverine and the imidazole derivative bendazole.

Papaverine is a myotropic antispasmodic. It is an inhibitor of the PED enzyme, which causes intracellular accumulation of cyclic 3′, 5′-adenosine monophosphate (cAMP). The accumulation of cAMP leads to impaired smooth muscle contractility and their relaxation in spastic conditions. It reduces tone, reduces the contractile activity of smooth muscles and, in this regard, has a vasodilator and antispasmodic effect. The effect of papaverine on the CNS is weak, only in high doses does it exhibit some sedative effect.

Bendazole is a myotropic antispasmodic. It directly affects the state of the smooth muscles of the vascular wall and internal organs by affecting imidazole receptors. It reduces blood pressure, the content of free calcium in smooth muscles, eliminates spasm of smooth muscles of the abdominal organs, stimulates the functions of the spinal cord. It increases the ability of tissues to resist hypoxia, increases the synthesis of nucleic acids and protein.

Spasms of smooth muscles of internal organs (pylorospasm, spastic colitis, cholecystitis, gastric and duodenal ulcer, intestinal colic, renal colic, urinary tract spasms);

• transient cerebral vascular spasm;
• moderately pronounced spasm of peripheral vessels;
• an additional remedy as part of the complex therapy of hypertension.

Assign adults orally 2 hours before or after meals, 1 tablet 2-3 times a day. Maximum single dose – 1 tablet, maximum daily dose – 4 tablets.

The duration of treatment is determined by the doctor depending on the nature and course of the disease, and the effectiveness of therapy.

Hypersensitivity to the active substance or to other components of the drug; AV conduction disorders; severe heart failure; arterial hypotension; diseases accompanied by a decrease in muscle tone; convulsive syndrome, bronchoobstructive syndrome, gastric and duodenal ulcers; hypotonic colitis; habitual constipation; craniocerebral trauma; severe hepatic and renal failure; chronic nephritis with edema and impaired nitrogen-excreting kidney function; diabetes mellitus; hypothyroidism; adrenal insufficiency, prostatic hypertrophy, glaucoma.

In the case of rare hereditary conditions that may cause incompatibility with the excipient of the medicinal product (see Special warnings and precautions for use), the medicinal product is contraindicated.

When using the drug, some patients may experience adverse reactions characteristic of papaverine and bendazole.

From the respiratory system, chest organs and mediastinum: dry cough, rhinorrhea, difficulty breathing.

Gastrointestinal: nausea, constipation, discomfort in the stomach area.

Liver and biliary tract: increased activity of hepatic transaminases, jaundice.

From the nervous system: headache, drowsiness, weakness, dizziness.

From the cardiovascular system: AV block, arrhythmias, decreased myocardial contractility, arterial hypotension, orthostatic hypotension, palpitations, pain in the heart area, hot flashes, ventricular extrasystole, tachycardia; with prolonged use – deterioration of ECG parameters due to decreased cardiac output.

Blood and lymphatic system disorders: eosinophilia.

Immune system disorders: hypersensitivity reactions, including rash, itching, urticaria, angioedema.

General disorders: increased sweating, flushing, feeling of heat.

The drug should be prescribed with caution and in doses below the average therapeutic dose, in severe heart diseases, supraventricular tachycardia, respiratory depression, decreased intestinal peristalsis, shock conditions, weakened patients and the elderly.

It is not recommended to use the drug for long-term treatment of hypertension, especially in elderly patients.

When taking the drug, the development of orthostatic hypotension is possible.

If symptoms of liver dysfunction appear, in particular, gastrointestinal disorders, jaundice, eosinophilia and increased liver enzymes, it is necessary to stop taking the drug.

You should inform your doctor about the following symptoms: hot flashes, increased sweating, headache, increased fatigue, jaundice, skin rash, nausea, stomach discomfort, constipation.

Smoking reduces the effectiveness of the medicine.

While taking the drug, you should avoid drinking alcohol and drugs that depress the CNS.

The medicine contains lactose, therefore patients with rare hereditary forms of galactose intolerance, lactase deficiency or glucose-galactose malabsorption syndrome should not take the medicine.

Use during pregnancy and breastfeeding. The drug is contraindicated during pregnancy or breastfeeding.

Children. The drug should not be used in children.

Ability to influence the speed of reactions when driving vehicles or other mechanisms. During treatment with the drug, you should refrain from driving vehicles or working with other complex mechanisms.

When using Papazol simultaneously with other medicines, the following types of interactions are possible:

with antihypertensive drugs of various groups, tricyclic antidepressants, saluretics, procainamide, reserpine, quinidine, phentolamine – increased hypotensive effect; with prolonged use with β-adrenergic blockers, the drug prevents the increase in total peripheral resistance caused by β-adrenergic blockers;

with anticholinergic agents – increased anticholinergic effect;

with barbiturates – mutual enhancement of effects;

with levodopa, methyldopa – weakening of the effects of these drugs;

with CNS depressant drugs – increased toxicity of these drugs, such a combination is not recommended;

with cardiac glycosides – pronounced increase in myocardial contractile function as a result of a decrease in total peripheral vascular resistance;

with adsorbents, astringents and enveloping agents – reducing the absorption of the drug from the gastrointestinal tract.

The effectiveness of the drug is reduced by smoking.

Symptoms of poisoning are a combination of an overdose of papaverine and bendazole.

Symptoms of bendazole poisoning: hypotension, arrhythmia, increased sweating, feeling hot, dizziness, nausea, headache, weakness, decreased tissue perfusion.

Symptoms of papaverine poisoning: anxiety, lethargy, drowsiness, weakness, headache, increased sweating, visual disturbances, diplopia, difficulty breathing, ataxia, nystagmus, central nervous system depression, sinus tachycardia, partial or complete AV block, hypotension, collapse, coma, cyanosis, metabolic acidosis, hyperventilation, hyperglycemia, hyperkalemia, nausea, vomiting, constipation, gastrointestinal disorders, skin rash.

Treatment: drug withdrawal, gastric lavage with clean lavage water, saline laxative and activated charcoal. Symptomatic treatment. There is no specific antidote.

Store at a temperature not exceeding 25 °C.