Pharmacological properties
The effect of the drug is due to the properties of its components. Biologically active substances of valerian and motherwort extracts (essential oils, saponins, alkaloids, tannins) have a beneficial effect on the functional activity of the central nervous system and the autonomic nervous system, exhibiting mainly sedative, anxiolytic and antispasmodic effects; regulate cardiac activity, reduce blood pressure and heart rate; suppress feelings of fear, mental stress, improve falling asleep and sleep structure. The pharmacological properties of hawthorn extract are due to the presence of flavonoids, choline, acetylcholine, phytosterols, triterpenic acids. Hawthorn extract is able to enhance blood circulation in the coronary and cerebral vessels, increase myocardial contractility (slight positive inotropic effect) and reduce its excitability (negative bathmotropic effect). Biologically active substances of hawthorn extract contribute to increasing myocardial tolerance to hypoxia, reduce peripheral vascular resistance and increase cardiac endurance in relation to physical exertion, have antiarrhythmic, hypotensive, hypocholesterolemic effects (reduce the level of cholesterol and triglycerides in the blood).
The drug has the ability to enhance the effects of other sedatives and hypnotics.
Indication
Mild forms of neurotic disorders accompanied by irritability, anxiety, feelings of fear, depression, fatigue, inattention, increased nervous excitability; mild forms of sleep disorders associated with the disorder; attacks of headaches, migraines caused by nervous tension, mild forms of dysmenorrhea, climacteric syndrome; neurocirculatory dystonia with tachycardia, cardialgia and angina pectoris; angina pectoris stage I; as part of complex therapy and prevention of chronic coronary artery disease, atherosclerosis, angina pectoris, supraventricular and ventricular arrhythmia, initial stages of chronic heart failure; dermatosis accompanied by itching (urticaria, atopic dermatitis, eczema); constant mental stress (manager’s syndrome).
Application
A single dose for adults and children over 12 years of age is 1 capsule 2-3 times a day. For mild forms of insomnia – 1 capsule 1 hour before bedtime. The maximum daily dose of the drug is 3 capsules.
The course of treatment depends on the form and severity of the disease, the nature of concomitant therapy, the achieved treatment effect and is determined individually.
Contraindication
Hypersensitivity to the components of the drug, severe arterial hypotension, severe bradycardia, depression and other diseases accompanied by suppression of the central nervous system.
Side effects
Allergic reactions: in patients with individual hypersensitivity to the components of the drug, allergic reactions may develop, including symptoms such as rash, itching, urticaria;
from the nervous system: dizziness, drowsiness;
from the cardiovascular system: tachycardia or bradycardia, decreased blood pressure are possible;
Gastrointestinal: nausea, vomiting, cramps.
If any negative effects occur, you should consult a doctor regarding further use of the drug!
Special instructions
Pregnancy and breastfeeding. The drug is not recommended for use due to insufficient data on the safety of use during pregnancy and breastfeeding.
Children: Do not use in children under 12 years of age.
The ability to influence the reaction rate when driving vehicles or working with other mechanisms. When using the drug, you should refrain from driving vehicles and working with potentially dangerous mechanisms.
Interactions
The drug enhances the activity of cardiac glycosides (digoxin), as well as the effects of antispasmodics, hypnotics and sedatives. The drug should not be used together with third-generation antiarrhythmics.
The drug may potentiate the pharmacological effects of analgesic and antihypertensive drugs, and also enhances the effects of alcohol.
Overdose
Symptoms: headache, dizziness, fatigue, lethargy, depression, weakness, decreased performance and concentration, drowsiness, abdominal pain, nausea, hand tremor, dilated pupils, feeling of tightness in the chest, bradycardia, decreased blood pressure; treatment: immediate discontinuation of the drug and timely emergency measures (gastric lavage, use of activated charcoal and desensitization agents), as well as symptomatic treatment contribute to the rapid elimination of clinical manifestations of overdose.
Storage conditions
At a temperature not exceeding 30 °C.









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