Lioton gel 1000 tube 50 g

Composition

• active ingredient: 1 g of gel contains 1000 IU of heparin sodium salt;
• excipients: ethanol 96%, carbomer 940, triethanolamine, methylparaben (E 218), propylparaben (E 216), neroli oil (contains linalool, d-limonene, geraniol, citral, citronellol and farnesol), lavender oil (contains linalool, d-limonene, geraniol and coumarin), purified water.

Release form

Gel.

Pharmacodynamics. Lioton 1000 gel, when applied to the skin, has an anti-edematous, anti-exudative, anti-inflammatory and anticoagulant effect.

Pharmacokinetics. Heparin is detected in blood plasma within 24 hours after application of the drug, with C _max of heparin in blood plasma reached after 8 hours. Excretion occurs mainly by the kidneys. The drug applied to the skin does not affect blood coagulation parameters.

Medical care for diseases of superficial veins, such as varicose veins and related complications, phlebothrombosis, thrombophlebitis, superficial periphlebitis; postoperative varicose phlebitis, complications after surgery for removal of the saphenous vein of the lower limb; injuries and bruises, infiltrates and localized edema, subcutaneous hematomas; injuries and sprains of the musculo-tendon and capsular-ligamentous apparatus.

Adults use the drug 1-3 times a day. Apply 3-10 cm of gel to the affected area of ​​the skin and rub in gently. The duration of treatment is determined by the doctor individually, taking into account the severity of the disease.

Hypersensitivity to heparin or any other component of the drug, bleeding trophic ulcers of the lower extremities, open and/or infected wounds, hemorrhagic diathesis, purpura, thrombocytopenia, hemophilia. bleeding tendency.

In some cases, hypersensitivity reactions may occur (hyperemia, itching and swelling of the skin, burning sensation, skin rash, urticaria, angioedema, hemorrhages, sometimes the appearance of small pustules, vesicles or blisters that quickly regress after discontinuation of the drug). When applied to large areas of the skin, systemic adverse reactions may occur.

As excipients, the drug contains methylparaben and propylparaben, so it cannot be used in case of allergy to parabens. If the patient has hemorrhagic symptoms, the possibility of using the drug Lioton 1000 gel should be carefully considered. The drug should not be used in case of bleeding, applied to open wounds, mucous membranes, infected areas of the skin in the presence of purulent processes, eyes and areas around the eyes, ulcers and blisters. In case of impaired blood clotting, the gel is not recommended to be applied to large areas of the skin. In case of phlebitis, the drug should not be rubbed into the skin.

Pregnancy and breastfeeding

There are no data on the use of the drug during pregnancy and breastfeeding.

Children

Due to limited experience, the drug is not recommended for use in children.

The ability to influence the reaction speed when driving or working with other mechanisms

The drug does not affect the ability to drive vehicles and work with other mechanisms.

Heparin may prolong prothrombin time in patients receiving oral anticoagulants. It should not be used concomitantly with topical medications, such as those containing tetracycline, hydrocortisone, salicylic acid, or anticoagulants.

Cases of overdose have not been described to date. Due to the insignificant systemic absorption, there is no risk of overdose of the drug when applied topically. Accidental oral administration of the gel (for example, by a child) may cause nausea or vomiting. In this case, the stomach should be washed and, if necessary, symptomatic therapy should be prescribed. The effect of heparin can be neutralized with protamine sulfate.

Does not require special storage conditions.