Ascorbic acid dragees 50 mg container 160 pcs

Pharmacodynamics. Ascorbic acid (vitamin C) has pronounced reducing properties. It belongs to the group of water-soluble vitamins. It participates in redox reactions, regulation of carbohydrate metabolism, affects the metabolism of aromatic amino acids, thyroxine metabolism, biosynthesis of catecholamines, steroid hormones and insulin, is necessary for blood clotting, synthesis of collagen and procollagen, regeneration of connective and bone tissue. Improves capillary permeability. Promotes iron absorption in the intestine and participates in the synthesis of hemoglobin. Increases nonspecific resistance of the body, has antidote properties. Vitamin C deficiency in food leads to the development of hypo- and avitaminosis C, since this vitamin is not synthesized in the body.

Pharmacokinetics. Absorption of ascorbic acid occurs mainly in the small intestine. The absorption process may be impaired in intestinal dyskinesia, enteritis, achilli, helminthic invasion, giardiasis, as well as when consuming alkaline drinks, fresh fruit and vegetable juices. C _max of the drug in blood plasma after oral administration is reached after 4 hours. Easily penetrates into leukocytes, platelets, and then into all tissues; deposited in the posterior pituitary, adrenal cortex, ocular epithelium, intermediate cells of the seminiferous glands, ovaries, liver, brain, spleen, pancreas, lungs, kidneys, intestinal wall, heart, muscles, thyroid gland. Metabolized mainly in the liver, into deoxyascorbic and further into oxaloacetic and diketogulonic acids. Unchanged ascorbate and metabolites are excreted in urine, feces, and also penetrate into breast milk. When used in high doses, when the concentration in the blood plasma reaches 1.4 mg / dl, excretion increases sharply, and increased excretion may persist after discontinuation of use.

Prevention and treatment of vitamin C deficiency. ensuring the body’s increased need for vitamin C during growth, pregnancy and breastfeeding; with increased physical and mental stress, with infectious diseases and intoxication, hemorrhagic diathesis, in complex therapy for bleeding (nasal, pulmonary, uterine); with radiation sickness, Addison’s disease, overdose of anticoagulants, with soft tissue injuries and infected wounds that heal slowly, bone fractures.

Inside after meals.

Adults and children over 14 years of age should take 1-2 tablets (50-100 mg) per day for prevention, children aged 3-14 years – 1 tablet (50 mg) per day.

Therapeutic doses for children over 14 years of age and adults are 1-2 tablets (50-100 mg) 3-5 times a day, for children aged 3-7 years – 1-2 tablets (50-100 mg) 2-3 times a day, at the age of 7-10 years – 2 tablets (100 mg) 2-3 times a day, at the age of 10-14 years – 2-3 tablets (100-150 mg) 2-3 times a day.

Pregnant women and women after childbirth and with low levels of vitamin C in breast milk should take 6 tablets (300 mg) per day for 10-15 days, then for prevention – 2 tablets (100 mg) per day throughout the entire breastfeeding period.

The duration of treatment depends on the nature and course of the disease and is determined by the doctor individually.

Hypersensitivity to ascorbic acid or any of the excipients of the drug, thrombosis, tendency to thrombosis, thrombophlebitis, diabetes mellitus, severe kidney disease, urolithiasis (when using 1 g/day), fructose intolerance, glucose-galactose malabsorption syndrome.

Gastrointestinal tract: when using 1 g/day – irritation of the mucous membrane of the digestive tract, heartburn, nausea, vomiting, diarrhea.

On the part of the kidneys and urinary system: damage to the glomerular apparatus of the kidneys, crystalluria, formation of urate, cystine and/or oxalate stones in the kidneys and urinary tract.

On the part of the immune system: Quincke’s edema, sometimes anaphylactic shock in the presence of sensitization.

Skin and subcutaneous tissue disorders: skin rash, itching, urticaria, eczema.

On the part of the endocrine system: damage to the insular apparatus of the pancreas (hyperglycemia, glucosuria) and impaired glycogen synthesis up to the development of diabetes mellitus.

From the cardiovascular system: arterial hypertension, myocardial dystrophy.

From the blood and lymphatic system: thrombocytosis, hyperprothrombinemia, thrombocytopenia, erythrocytopenia, neutrophilic leukocytosis; in patients with glucose-6-phosphate dehydrogenase deficiency, red blood cell hemolysis may occur, hemolytic anemia (in patients with glucose-6-phosphate dehydrogenase deficiency).

From the nervous system: increased excitability, sleep disturbances, headache, feeling of heat, fatigue.

Metabolic disorders: zinc and copper metabolism disorders.

When using the drug in high doses and for a long time, it is necessary to monitor kidney function and blood pressure, as well as pancreatic function. The drug should be used with caution in patients with a history of kidney disease.

In case of urolithiasis, the daily dose of ascorbic acid should not exceed 1 g.

The drug should not be prescribed in high doses to patients with increased blood clotting.

Since ascorbic acid increases iron absorption, its use in high doses can be dangerous for patients with hemochromatosis, thalassemia, polycythemia, leukemia and sideroblastic anemia. Patients with high iron levels in the body should use the drug in minimal doses.

Simultaneous use of the drug with alkaline drinks reduces the absorption of ascorbic acid, so you should not drink it with alkaline mineral water. Also, the absorption of ascorbic acid may be impaired in intestinal dyskinesia, enteritis and achilia.

Use with caution in patients with glucose-6-phosphate dehydrogenase deficiency.

Ascorbic acid as a reducing agent can affect the results of various laboratory tests, for example, when determining the blood content of glucose, bilirubin, transaminase activity, and LDH.

Since ascorbic acid has a mild stimulating effect, it is not recommended to use the drug at the end of the day. Due to the stimulating effect of ascorbic acid on the formation of corticosteroid hormones, when using the drug in high doses, monitoring of kidney function and blood pressure is required.

Use during pregnancy or breastfeeding. The drug can be used during pregnancy or breastfeeding according to the dosage recommendations and doctor’s prescription. It is necessary to strictly adhere to the recommended doses and not exceed them.

Children. The drug is used in children over 3 years of age.

The ability to influence the speed of reactions when driving vehicles or working with other mechanisms. Does not affect.

Ascorbic acid, when administered orally, increases the absorption of penicillin, tetracycline, and iron; promotes the absorption of aluminum in the intestines, which should be taken into account during simultaneous treatment with antacids containing aluminum.

The simultaneous use of vitamin C and deferoxamine increases tissue iron toxicity, especially in the heart muscle, which can lead to circulatory decompensation. Vitamin C can be used only 2 hours after the injection of deferoxamine.

Prolonged use in high doses by individuals taking disulfiram inhibits the disulfiram/alcohol reaction.

High doses of the drug reduce the effectiveness of tricyclic antidepressants, neuroleptics – phenothiazine derivatives, tubular reabsorption of amphetamine, disrupt the excretion of mexiletine by the kidneys, and affect the resorption of vitamin _B12.

Ascorbic acid increases the total clearance of ethyl alcohol.

The drug reduces the toxicity of sulfonamide drugs, as well as the effectiveness of heparin and indirect anticoagulants.

Vitamin C increases the excretion of oxalates in the urine, thus increasing the risk of oxalate stone formation in the urine, and increases the risk of crystalluria during treatment with salicylates.

Quinoline drugs, calcium chloride, salicylates, and corticosteroids, when used for long periods of time, reduce the body’s stores of ascorbic acid.

Absorption of ascorbic acid is reduced with the simultaneous use of oral contraceptives, consumption of fruit or vegetable juices, and alkaline drinks.

Ascorbic acid is well tolerated. It is a water-soluble vitamin, and excess amounts are excreted in the urine.

Symptoms. With prolonged use of vitamin C in high doses, inhibition of the function of the insular apparatus of the pancreas is possible, which requires monitoring of the condition of the latter. Overdose can lead to changes in the renal excretion of ascorbic and uric acids during urine acetylation with the risk of precipitation of oxalate stones.

The use of the drug in high doses may lead to vomiting, nausea, or diarrhea, which disappear after its withdrawal.

Treatment: Symptomatic therapy.

In the original packaging at a temperature not exceeding 25 °C.