Diclofenac rectal suppositories 0.1 g 2 blisters of 5 pcs.

• 1 suppository contains diclofenac sodium 100 mg (0.1 g);
• excipient: solid fat.

• hypersensitivity to the active substance or to any excipient;
• history of gastrointestinal bleeding or perforation related to previous NSAID treatment;
• active ulcer/bleeding or history of recurrent ulcer/bleeding (two or more separate episodes of established ulceration or bleeding);
• inflammatory bowel diseases (such as Crohn’s disease or ulcerative colitis);
• 3rd trimester of pregnancy;
• proctitis.

The initial dose is usually 100-150 mg per day. With mild symptoms, as well as with long-term therapy, a dose of 75-100 mg/day is sufficient.

The concomitant use of diclofenac with systemic NSAIDs such as selective cyclooxygenase-2 inhibitors should be avoided due to the lack of any evidence of a synergistic effect and due to potential additive side effects.

Pregnant women

In the first and second trimesters of pregnancy, Diclofenac should be prescribed only if the expected benefit to the pregnant woman outweighs the potential risk to the fetus, and only in the minimum effective dose; the duration of treatment should be as short as possible.

Diclofenac is contraindicated in the third trimester of pregnancy.

Children

The drug is not used in children.

Drivers

Patients who experience visual disturbances, dizziness, vertigo, drowsiness, central nervous system disorders, lethargy or fatigue during Diclofenac therapy should not drive or operate complex machinery.

Overdose may cause vomiting, gastrointestinal bleeding, diarrhea, dizziness, tinnitus, and convulsions. Acute renal failure and liver damage are possible in cases of severe intoxication. Treatment of acute NSAID poisoning consists of supportive and symptomatic therapy.

From the blood and lymphatic system: thrombocytopenia, leukopenia, anemia (hemolytic anemia, aplastic anemia), agranulocytosis.

Immune system disorders: hypersensitivity, anaphylactic and anaphylactoid reactions (including hypotension and shock); angioedema (including facial edema).

Mental disorders: disorientation, depression, insomnia, irritability, nightmares, psychotic disorders.

Nervous system: headache, dizziness; drowsiness, fatigue; paresthesia, memory impairment, convulsions, anxiety, tremor, aseptic meningitis, taste disorders, stroke; confusion, hallucinations, sensory disturbances, general malaise.

Store out of the reach of children at a temperature not exceeding 25°C.