Dimethyl sulfoxide gel 250 mg/g tube 30 g

• active ingredient: dimethyl sulfoxide;
• 1 g of gel contains 250 or 500 mg of dimethyl sulfoxide.
• Excipients: sodium carmellose, mint flavoring, purified water.

Hypersensitivity to dimethyl sulfoxide and other components of the drug, severe hepatic and/or renal failure, cardiovascular failure, angina pectoris, severe atherosclerosis, glaucoma, cataracts, myocardial infarction, stroke, coma, pregnancy, breastfeeding, age up to 12 years.

Dimethyl sulfoxide is usually well tolerated, but some patients may experience:

On the part of the immune system: allergic reactions, including dermatitis, skin rash, angioedema, increased skin pigmentation, itching, burning, skin hyperemia, erythema, dry skin.

Gastrointestinal: temporary garlic odor from the mouth (due to the action of dimethyl sulfide, a metabolite of dimethyl sulfoxide), nausea, vomiting, diarrhea.

From the side of the central and peripheral nervous system: headache, dizziness, insomnia, adynamia.

Respiratory system: bronchospasm.

The drug is for external use. Adults and children over 12 years of age apply a thin layer of gel to the affected area 1–2 times a day and rub in gently. For use on sensitive areas, use a gel with a dimethyl sulfoxide concentration of 250 mg/g. Duration of treatment is 10–14 days. Repeated courses can be carried out no earlier than after 10 days.

Given the possibility of individual intolerance to the drug, it is recommended to conduct a drug test for tolerance. To do this, the gel is applied to a small area of ​​skin on the back of the wrist. The appearance of sharp hyperemia and itching indicates hypersensitivity to the drug.

If a patient is hypersensitive, medications containing dimethyl sulfoxide should not be prescribed. If allergic reactions occur during treatment, the drug is discontinued.

Do not apply to damaged skin or skin with allergic manifestations. Do not apply to facial skin.

Avoid contact with mucous membranes and eyes. In case of accidental contact, rinse immediately with water.

It is prescribed with caution to patients with a severe allergic history, as well as to people suffering from ischemic heart disease.

Due to the fact that dimethyl sulfoxide can enhance not only the activity, but also the toxicity of some drugs, it should be prescribed with caution simultaneously with other topical agents.

Use during pregnancy or breastfeeding

Contraindicated during pregnancy or breastfeeding. Breastfeeding should be discontinued during treatment with the drug.

Children

Do not use in children under 12 years of age.

Ability to influence reaction speed when driving vehicles or other mechanisms

It should be used with caution, taking into account the effects on the central nervous system, in particular the possibility of dizziness.

Overdose of the drug may cause increased side effects. In this case, it is necessary to stop using the drug, wash the treated area of ​​​​skin. Treatment is symptomatic.

Dimethyl sulfoxide enhances the effect of ethanol (alcohol inhibits the excretion of the drug) and insulin, acetylsalicylic acid, butadione; digitalis, quinidine, nitroglycerin. Increases the level of absorption and enhances the effects of other local drugs applied simultaneously. Compatible with heparin, antibacterial drugs, nonsteroidal anti-inflammatory drugs. The drug DIMETHYL SULFOXIDE cannot be used with sulindac (nonsteroidal anti-inflammatory drug) due to the possibility of severe toxic reactions (peripheral neuropathy). Increases the sensitivity of microorganisms to aminoglycosides and beta-lactam antibiotics, chloramphenicol, rifampicin, griseofulvin. Sensitizes the body to the effects of drugs for general and local anesthesia.

Store at a temperature not exceeding 25 ° C. Keep out of the reach of children.