Dvatse Long granules for oral solution 600 mg sachet 3 g pack of 10 pcs.

• active ingredient: acetylcysteine;
• 1 sachet contains 600 mg of acetylcysteine;
• excipients: sorbitol (E 420), acesulfame potassium, orange flavoring.

Known hypersensitivity to acetylcysteine ​​or to any of the excipients of the drug. Gastric and duodenal ulcer in the acute stage, hemoptysis, pulmonary hemorrhage, severe exacerbation of bronchial asthma.

From the side of the organs of hearing and vestibular apparatus: infrequently – tinnitus.

Respiratory, thoracic and mediastinal disorders: rarely – dyspnoea, bronchospasm (mainly in patients with bronchial hyperreactivity associated with bronchial asthma); frequency unknown – rhinorrhea.

Gastrointestinal: infrequently – heartburn, stomatitis, abdominal pain, nausea, vomiting, diarrhea; rarely – dyspepsia; frequency unknown – bad breath.

From the nervous system: infrequently – headache.

From the cardiovascular system: infrequently – tachycardia, arterial hypotension; very rarely – hemorrhages.

Blood and lymphatic system disorders: frequency unknown – anemia.

On the part of the immune system: infrequently – hypersensitivity; very rarely – anaphylactic shock, anaphylactic/anaphylactoid reactions.

Skin and subcutaneous tissue disorders: infrequently – itching, urticaria, exanthema, rashes, angioedema (Quincke’s edema); frequency unknown – eczema.

General disorders: infrequently – hyperthermia; frequency unknown – facial edema.

In very rare cases, severe skin reactions (e.g. Stevens-Johnson syndrome and Lyell’s syndrome) have been reported in association with the use of acetylcysteine.

Adults and children over 12 years of age – prescribe 600 mg once a day.

It is recommended to take the medicine after meals.

Dissolve the granules in a glass of water and drink the solution without delay, immediately after preparation.

When dissolving acetylcysteine, it is necessary to use glassware and avoid contact with metal and rubber surfaces.

Additional fluid intake enhances the mucolytic effect of the drug.

The duration of the course of treatment is determined by the doctor individually, depending on the nature of the disease. In acute uncomplicated diseases, acetylcysteine ​​is used for 4–5 days.

Use during pregnancy or breastfeeding

The drug should be used during pregnancy or breastfeeding only after careful assessment of the benefit/risk ratio.

Children

Use in children over 12 years of age.

Ability to influence reaction speed when driving vehicles or other mechanisms

There is no evidence that acetylcysteine ​​affects the ability to drive and use other mechanisms.

There are no data on cases of overdose with oral administration of acetylcysteine.

Acetylcysteine, when used at a dose of 500 mg/kg/day, does not cause overdose.

Symptoms.

Overdose may manifest as gastrointestinal symptoms such as nausea, vomiting and diarrhea. Children are at risk of hypersecretion.

Treatment.

There is no specific antidote for acetylcysteine ​​poisoning; therapy is symptomatic.

It is not recommended to dissolve acetylcysteine ​​with other medications in the same glass.

Interaction studies were conducted only with adults.

The use of antitussives with acetylcysteine ​​may increase sputum congestion due to suppression of the cough reflex.

Activated charcoal reduces the effectiveness of acetylcysteine.

When used simultaneously with antibiotics such as tetracyclines (except doxycycline), ampicillin, amphotericin B, cephalosporins, aminoglycosides, their interaction with the thiol group of acetylcysteine ​​is possible, which leads to a decrease in the activity of both drugs. Therefore, the interval between the use of these drugs should be at least 2 hours. This does not apply to cefixime and loracarbef.

With simultaneous use of nitroglycerin and acetylcysteine, significant hypotension and dilation of the temporal artery have been observed. If it is necessary to use nitroglycerin and acetylcysteine ​​simultaneously, patients should be monitored for hypotension, which may be severe, and the possibility of headache should be taken into account.

Store in the original packaging at a temperature not exceeding 25 °C.

Keep out of reach of children.