Liv.52 tablets 100 pcs.

Pharmacodynamics. A combined herbal preparation, the effect of which is due to the properties of the components that make up its composition.

Herbaceous capers contain thioglycosides, steroidal saponins, rutin, ascorbic acid, quercetin and have hepatostimulating, hepatoprotective, diuretic, antiseptic, analgesic effects, and improve appetite.

Wild chicory contains glycosides, fructose, levulose, choline, ascorbic acid, B vitamins. Chicory stimulates appetite, improves digestive function, especially in gastritis, enteritis, colitis, exhibits hypoglycemic, hepatoprotective effects, is useful in cholecystitis (stimulates bile secretion), kidney diseases (diuretic effect). Chicory enhances the effect of capers.

Black nightshade contains glycoalkaloids, rutin, asparagine, sitosterol, tannins, saponins, citric acid, ascorbic acid. It has antispasmodic, analgesic, diuretic, emollient, anti-inflammatory and hepatoprotective effects.

The composition of western cassia includes anthraglycosides, flavonoids, sterols, organic acids. It has choleretic, antitoxic, laxative effects. Cassia is effective in case of impaired bile flow into the intestines. It does not change the normal function of the small intestine, does not cause constipation after laxative action (tonic effect on the gastrointestinal tract).

Terminalia Arjuna has a diuretic effect and a tonic effect.

Tamarix cali has hepatoprotective properties.

Yarrow contains essential oil, flavonoids, tannins, vitamin K. Causes dilation of the bile ducts, increases bile secretion into the duodenum, increases diuresis, eliminates spastic pain in the intestines. Tones up the function of the gastrointestinal tract, has an anti-inflammatory effect. Due to these properties, it is used for hypoacid gastritis, gastric ulcer and duodenal ulcer, spastic ulcerative colitis, flatulence, liver and kidney diseases. Iron oxide stimulates hematopoiesis.

In general, Liv.52 has hepatoprotective, antitoxic, anti-inflammatory, choleretic effects. Improves the digestive process, stimulates hematopoiesis. The hepatoprotective effect is due to the antioxidant and membrane-stabilizing properties of the components included in the preparation. The preparation reduces the degradation of cell membranes caused by (nicotinamide dinucleotide phosphate) NADPH-dependent lipid peroxidation, increases the content of antioxidants in hepatocytes, prevents the formation of free radicals.

Antitoxic action is based on protection of EPR of hepatocytes. The drug normalizes and increases the content of cytochrome P450. In case of alcohol intoxication, it increases the elimination of acetaldehyde. In case of chronic alcoholism, it prevents the infiltration of lipids into liver cells. It protects the liver from carbon tetrachloride. In the pre-cirrhotic phase, it delays the development of the disease and prevents further liver damage.

Liv.52 stimulates the synthesis of protein, cholesterol, phospholipids, promotes the regeneration of liver cells, restores their functional ability. The drug improves appetite, facilitates the passage of gases from the intestines. Increases body weight during exhaustion.

Pharmacokinetics. The action of the drug Liv.52 is the combined effect of the components that make up its composition. This combination ensures the activity and synergy of its herbal ingredients. Kinetic studies are not possible; the combination of components cannot be studied using markers or bioassays. For the same reason, it is impossible to detect the metabolites of the drug.

Prevention and treatment of chronic diffuse liver diseases; alcoholic liver damage, radioactive and chemotherapeutic liver damage. as a hepatoprotective agent in toxic liver damage, to accelerate recovery during the recovery period after serious illnesses, surgeries. cholecystoangiocholitis and biliary dyskinesia.

Liv.52 tablets are taken orally.

Adults and children over 14 years old – 2 tablets 3 times a day, children 5-14 years old – 1 tablet 3 times a day. The duration of treatment is determined by the doctor depending on the disease and the severity of the course of the disease.

For alcoholic liver damage, adults take 2 tablets 3 times a day for a month, then 1 tablet 3 times a day for 6-12 months.

Hypersensitivity to individual components of the drug. Children under 5 years of age.

Dyspeptic symptoms and allergic reactions are possible.

There are reports of the development of epidermal necrolysis in patients with chronic or acute infectious hepatitis who took Liv.52.

Use during pregnancy and breastfeeding. Clinical data on the safety of the drug for treatment during pregnancy and breastfeeding are lacking.

When Liv.52 and ibuprofen are used simultaneously, the level of the latter in the body decreases due to delayed absorption. When used simultaneously with tetracycline or doxycycline, the bioavailability of antibiotics decreases.

Long-term use, as well as an overdose, does not cause toxic effects. There is no antidote.

In a dry place, protected from light, at a temperature of 10-30 °C.