Okomistyn eye/ear/nasal drops solution 0.01% bottle 10 ml

Pharmacodynamics. Miramistin is a cationic surfactant with antimicrobial (antiseptic) action.

The action of Miramistin is based on the direct hydrophobic interaction of the molecule with the lipids of the membranes of microorganisms, which leads to their fragmentation and destruction. At the same time, part of the Miramistin molecule, immersing in the hydrophobic area of ​​the membrane, destroys the supramembrane layer, loosens the membrane, increases its permeability for large molecular substances, changes the enzymatic activity of the microbial cell, inhibits enzyme systems, which leads to the suppression of the vital activity of microorganisms and their cytolysis.

Unlike other antiseptics, Miramistin has a high selectivity of action against microorganisms, because it practically does not act on the membranes of human cells. This effect is associated with a different structure of human cell membranes (a significantly longer length of lipid radicals, which sharply limits the possibility of hydrophobic interaction of Miramistin with cells).

Miramistin has a pronounced antimicrobial effect against gram-positive and gram-negative, aerobic and anaerobic, spore-forming and asporogenic bacteria in the form of monocultures and microbial associations, including hospital strains with multidrug resistance to antibiotics.

It has a detrimental effect on pathogens of sexually transmitted diseases – gonococci, pale treponema, trichomonads, chlamydia, as well as herpes viruses, human immunodeficiency. It has an antifungal effect on ascomycetes of the genus Aspergillus and the genus Penicillum, yeast (Rhodotorula rubra, Torulopsis gabrata) and yeast-like (Candida albicans, Candida krusei) fungi, dermatophytes (Trichophyton rubrum, Trichophyton mentagrophytes, Trichopphyton verrucosum, T. schoenleini, T. violaceum, Epidermophyton Kaufman – Wolf, E. floccosum, Microsporum gypscum, Microsporum canis), as well as on other pathogenic fungi (for example, Pityrosporum orbiculare (Malassezia furfur)) in the form of monocultures and microbial associations, including fungal microflora with resistance to chemotherapeutic drugs. Under the action of Miramistin, the resistance of microorganisms to antibiotics decreases. Miramistin has an anti-inflammatory and immunoadjuvant effect, enhances local protective reactions, regenerative processes, activates nonspecific defense mechanisms due to the modulation of cellular and local humoral immune responses, which accelerates recovery.

Pharmacokinetics. Miramistin has a local effect. There is no data on the possibility of the drug penetrating into the systemic bloodstream.

In the complex treatment of infectious processes of the anterior segment of the eye (blepharitis, conjunctivitis, keratitis, keratouveitis) caused by gram-positive and gram-negative bacteria, chlamydia, fungi and viruses sensitive to Miramistin, eye injuries, eye burns (thermal and chemical).

Prevention of ophthalmia in newborns, including gonococcal and chlamydial ophthalmia.

Prevention and treatment of purulent-inflammatory eye lesions in the pre- and postoperative period.

In the complex treatment of acute and chronic otitis externa, chronic purulent mesotympanitis, otomycosis.

In the complex treatment of acute rhinitis.

Ophthalmology. For the treatment of infectious processes of the anterior segment of the eye, adults and children over 12 years of age are instilled into the conjunctival sac 2-3 drops, children under 12 years of age – 1-2 drops 4-6 times a day. The duration of treatment usually does not exceed 2 weeks.

To prevent complications in the pre- and postoperative period – 2-3 drops 3 times a day for 2-3 days before the operation. After the operation – 1-2 drops 3 times a day for 3-5 days.

To treat eye burns, after rinsing the eye with plenty of water, frequent instillations (every 5-10 minutes) are performed for 1-2 hours. For further treatment, the drug is used in adults and children over 12 years of age – 2-3 drops, in children under 12 years of age – 1-2 drops 4-6 times a day.

To prevent ophthalmia in newborns, immediately after birth, the child is instilled with 1 drop of the drug in each eye 3 times with an interval of 2-3 minutes.

Otolaryngology. In the treatment of acute and chronic external otitis, otomycosis, adults and children over 12 years of age are instilled with 3-5 drops 4-6 times a day, children under 12 years of age – 2-3 drops 4-6 times a day.

A gauze swab moistened with the drug can be inserted into the external auditory canal 4-6 times a day for 10-14 days (instead of instillation).

In chronic mesotympanitis, it is used in complex treatment using hardware ultrasonic irrigation or injection into the tympanic cavity in combination with antibiotics.

In the treatment of acute rhinitis, infections of the nasal mucosa, adults and children over 12 years of age are instilled with 2-3 drops, children under 12 years of age – 1-2 drops in each nostril 4-6 times a day. The course of treatment is 7-14 days.

Dosage features. Accurate dosing is achieved by pressing the bottom of the bottle – one press = 1 drop.

Children. The drug can be used in pediatric practice.

Individual sensitivity to the components of the drug.

When using the drug, hypersensitivity reactions are possible. In some cases, a short-term burning sensation is possible, which disappears on its own after 15-20 seconds and does not require discontinuation of treatment.

If any adverse reactions occur, you should consult a doctor!

Use during pregnancy and breastfeeding. Can be used during pregnancy. There is no data on the negative effects of the drug during breastfeeding.

Ability to influence the speed of reactions when driving vehicles or working with other mechanisms. The drug does not affect the speed of reactions when driving vehicles or working with other mechanisms.

When used simultaneously, Okomistin® increases the effectiveness of topical antibiotics.

If you are taking any other medications at the same time, you should inform your doctor.

Not observed.

At a temperature not exceeding 35 °C in the original packaging, out of the reach of children. Keep the bottle tightly closed between uses.