Ukrliv oral suspension is prescribed for the following indications:
- Symptomatic treatment of primary biliary cirrhosis (PBC) in the absence of decompensated liver cirrhosis.
- For the dissolution of radiopaque cholesterol gallstones no larger than 15 mm in diameter in patients with a functioning gallbladder, despite the presence of a gallstone in it.
- For the treatment of hepatobiliary disorders in cystic fibrosis in children aged 1 month to 18 years.
Composition
Active ingredient: ursodeoxycholic acid;
5 ml of suspension contain ursodeoxycholic acid 250 mg;
Excipients: microcrystalline cellulose-sodium carboxymethylcellulose, benzoic acid (E 210), xylitol, glycerin, sodium saccharin, sodium chloride, citric acid monohydrate, sodium, lemon flavor, purified water.
Contraindication
- Hypersensitivity to bile acids or to any of the excipients.
- Acute cholecystitis or acute cholangitis.
- Biliary obstruction (blockage of the common bile duct or ducts).
- Frequent attacks of biliary (hepatic) colic.
- The presence of radiopaque calcified gallstones.
- The contractility of the gallbladder is impaired.
- Unsuccessful outcome of portoenterostomy or lack of adequate biliary outflow in children with biliary atresia.
Method of application
To administer the required dose using a syringe
- Before opening the bottle, the suspension must be shaken.
- Next, you need to pour a small amount of suspension into a measuring spoon.
- Draw a little more suspension into the syringe than needed.
- Press the syringe plunger with your finger to remove air bubbles from the withdrawn suspension.
- Check the volume of suspension in the syringe and adjust if necessary.
- Carefully insert the contents of the syringe directly into the child’s mouth.
Do not draw the syringe directly from the vial. Do not pour unused suspension from the measuring spoon or syringe back into the vial.
Application features
Pregnant women
Should not be used.
Children
Apply to children from 1 month of age.
Drivers
Does not affect.
Overdose
Overdose may cause diarrhea. Overdose is unlikely, as the absorption of ursodeoxycholic acid decreases with increasing dose and most of it is excreted in the feces.
In case of diarrhea, the dose should be reduced; if diarrhea persists, therapy should be discontinued.
No specific countermeasures are necessary; the effects of diarrhea should be treated symptomatically, maintaining fluid and electrolyte balance.
Side effects
Gastrointestinal: loose stools or diarrhea, severe pain in the right upper abdomen.
Liver and gallbladder: calcification of gallstones, decompensation of liver cirrhosis, which partially regressed after discontinuation of treatment.
Interaction
Estrogen hormones, as well as drugs to reduce cholesterol concentration in the blood, can increase the secretion of cholesterol by the liver and, thus, contribute to the formation of gallstones, which is the opposite effect of ursodeoxycholic acid, which is used to dissolve them.
Storage conditions
Store at a temperature not exceeding 25 °C in the original packaging.
Keep out of reach of children.
After opening the bottle or jar, store the drug for no more than 4 months.
Shelf life – 2 years.













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